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Covalent biofunctionalisation of hydroxyapatite scaffolds via plasma technology (Abstract/Poster in atti di convegno)

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Covalent biofunctionalisation of hydroxyapatite scaffolds via plasma technology (Abstract/Poster in atti di convegno) (literal)

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Nicotra F.; Russo L.; Shaikh N.; Cipolla L.; Zanini S.; Riccardi C.; Ziano R.; Valentini F.; Landi E. (2009)
Covalent biofunctionalisation of hydroxyapatite scaffolds via plasma technology
in 22nd European Conference on Biomaterials (European Society of Biomaterials), Lausanne, CH
(literal)

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Nicotra F.; Russo L.; Shaikh N.; Cipolla L.; Zanini S.; Riccardi C.; Ziano R.; Valentini F.; Landi E. (literal)

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In: ESB 2009 - 22nd European Conference on Biomaterials (European Society of Biomaterials) (Lausanne, CH, 07-11th September 2009). Abstract, article n. abstract CD. The European Society for Biomaterials (ESB), 2009. (literal)

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The knowledge of articular cartilage, calcified cartilage and bone tissue architectures as well as the biological mechanisms involved in the maintenance of their structure and function is essential for the design of new biomaterial scaffolds with properties such as tissue compatibility, regeneration induction and growth that could potentially enhance innate restorative capacity. It has been widely described the ability of bioceramics such as hydroxyapatite (HA) and bioactive glass ceramics to form a bonding with the surrounding bone tissue [1]. However, these materials alone do not match the specific requirements of bone tissue and specially the calcified cartilage interface. For this reason, researchers try to combine these inorganic materials with organic matrices that can improve cell-biomaterial scaffold interactions thereby enhancing new tissue growth. In addition, stable linking of ligands to a surface is essential to promote cell interactions with the surface of biomaterials, in order to avoid the redistribution of weakly adsorbed ligands. Derivatization of bioceramics for ligand introduction ideally should allow covalent linkage to the inorganic matrices e.g. via functional groups like hydroxyl-, amino-, or carboxyl groups. A possibility to introduce modifiable groups on the hydroxyapatite scaffold is plasma deposition. We then studied the possibility to functionalise by plasma technology a 3D scaffold of hydroxyapatite (literal)

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