http://www.cnr.it/ontology/cnr/individuo/prodotto/ID120228

New magnetic scaffold for bone regeneration (Comunicazione a convegno)

Type

Comunicazione a convegno (Classe)
Prodotto della ricerca (Classe)

Label

New magnetic scaffold for bone regeneration (Comunicazione a convegno) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Alternative label

Tampieri A.; Landi E.; Valentini F.; Sandri M. (2009)
New magnetic scaffold for bone regeneration
in European Congress and Exhibition on Advanced Materials, Glasgow, Scotland
(literal)

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Tampieri A.; Landi E.; Valentini F.; Sandri M. (literal)

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In: EUROMAT 2009 - European Congress and Exhibition on Advanced Materials (Glasgow, Scotland, 07-10 settembre 2009). (literal)

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The major limitations of the scaffolds for bone and cartilage regeneration nowadays available in the market are related to the difficulties in controlling cell differentiation and angiogenesis processes and to obtain stable scaffold implantation in the pathological site. Several attempts have been performed over the last years in order to provide scaffolds for tissue engineering, but presently there is no way to grant that tissue regeneration will take place in the pathological site. The in vivo provision of the scaffold with stem cells or/and growth factors in order to drive the tissue differentiation process and ensuing angiogenesis represents a most challenging request [Ref. EC Nanomedicine roadmap]. The tissue engineering is a complex multi-steps process, which requires a long regeneration time in order to re-create the full functionality of the damaged tissues. The driving idea of this paper is the creation of a conceptually new type of scaffolds able to be manipulated in situ by means of magnetic forces. This approach is expected to generate scaffolds with such characteristics as multiple use and possibly multipurpose delivery in order to repair large bone defects and sub-chondral lesions in the articular surface of the skeletal system. In addition to that, magnetic scaffolds will give rise to few very important options that can hardly be addressed by other methods. One of such aspects is the fascinating possibility to achieve efficient scaffold fixation via magnetic forces. This shall provide a very elegant and simple solution to the fixation problem. Indeed, the scaffold fixation represents a problem due to the difficulties to obtain a stable interface between the host bone and the scaffold because of their different physical characteristics. As basic scaffold a bio-hybrid composite hydroxyapatite/collagen (HA/ Coll) was selected prepared by in vitro mineralization process and magnetic nono-particles were added simultaneously to the mineral phase nucleation (literal)

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