Ice-templated HA scaffolds as bone substitutes with drug delivery functions (Comunicazione a convegno)

Type
Label
  • Ice-templated HA scaffolds as bone substitutes with drug delivery functions (Comunicazione a convegno) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Valentini F.; Landi E.; Tampieri A.; Tonelli D. (2009)
    Ice-templated HA scaffolds as bone substitutes with drug delivery functions
    in European Congress and Exhibition on Advanced Materials, Glasgow, Scotland
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Valentini F.; Landi E.; Tampieri A.; Tonelli D. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: EUROMAT 2009 - European Congress and Exhibition on Advanced Materials (Glasgow, Scotland, 07-10 settembre 2009). (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Apatite scaffolds with complex porous macro- and micro-structures have been obtained by controlling the freezing of ceramics slurries and then performing ice sublimation and sintering. The morphological chemico-physical and mechanical characteristics of the scaffolds have been varied acting on various factors that influence the process. In general the scaffolds can show architectures ranging from narrow isotropic cellular to wide anisotropic channel like. Biomimetic substituted apatites are per sé systems delivering and releasing in situ ions with specific biological functions for bone (besides the main constituents calcium and phosphorous, they can include carbonate, magnesium, strontium, etc.). The ion release kinetic depends on the scaffold properties that influence the solubility. Besides the intrinsic delivery function, an antibiotic release can be included. Different procedures have been experimented to load tobramycin, an important antibiotic widely used for the treatment of osteomyelitis, in the scaffolds and to control and modulate the drug release in synthetic body fluid. A high performance liquid chromatography (HPLC) method exploiting an anionic column and a pulsed detector (PAD) has been used to follow the tobramycin release. Analytical methods based on high performance liquid chromatography (HPLC) have been developed to follow the release of the apatite ions and of the antibiotic, using respectively conductimetric and amperometric detectors (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR-ISTEC, Faenza, Department of Physical and Inorganic Chemistry, University of Bologna (literal)
Titolo
  • Ice-templated HA scaffolds as bone substitutes with drug delivery functions (literal)
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