Tethering functional ligands onto shell of ultrasound active polymeric microbubbles (Articolo in rivista)

Type
Label
  • Tethering functional ligands onto shell of ultrasound active polymeric microbubbles (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cavalieri, F; El Hamassi, A; Chiessi, E; Paradossi, G; Villa, R; Zaffaroni, N (2006)
    Tethering functional ligands onto shell of ultrasound active polymeric microbubbles
    in Biomacromolecules
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cavalieri, F; El Hamassi, A; Chiessi, E; Paradossi, G; Villa, R; Zaffaroni, N (literal)
Pagina inizio
  • 604 (literal)
Pagina fine
  • 611 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 7 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, I-00173 Rome, Italy; INFM, I-00173 Rome, Italy; Ist Nazl Studio & Cura Tumori, I-20133 Milan, Italy (literal)
Titolo
  • Tethering functional ligands onto shell of ultrasound active polymeric microbubbles (literal)
Abstract
  • Hollow (air-filled) microparticles, i.e., microbubbles, provide a promising novel vehicle for both local delivery of therapeutic agents and simultaneous diagnostic ultrasound echo investigations. In this paper, we describe the synthetic routes for decorating the polymeric shell of a poly(vinyl alcohol)-based microbubble with low and high molecular weight ligands with pharmacological relevance. Investigations on physical properties of microbubbles and surface chemical coupling with different cargo molecules such as L-Cysteine, L-lysine, poly(L-lysine), chitosan, and beta-cyclodextrin were carried out by CD and NMR spectroscopies, confocal laser scanning microscopy, and microcalorimetry. The in vitro cytotoxicity and biocompatibility of the polymer microbubbles have been also determined toward different cell lines. The results are discussed in terms of the features shown by this device, i.e., injectability, long shelf life, ease of preparation, biocompatibility, loading and cargo capacities, and functional properties. (literal)
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