The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• The ENFUMOSA Study Group (European Network for Understanding Mechanisms of Severe Asthma) (2003)
  The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma.
  in The European respiratory journal
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• The ENFUMOSA Study Group (European Network for Understanding Mechanisms of Severe Asthma) (literal)

Pagina inizio

• 470 (literal)

Pagina fine

• 477 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• ?The ?European respiratory journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR IBIM, Palermo (literal)

Titolo

• The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. (literal)

Abstract

• Since severe asthma is a poorly understood, major health problem, 12 clinical specialist centres in nine European countries formed a European Network For Understanding Mechanisms Of Severe Asthma (ENFUMOSA). In a cross-sectional observational study, a total of 163 subjects with severe asthma were compared with 158 subjects whose asthma was controlled by low doses of inhaled corticosteroids (median dose of beclomethasone equivalents 666 microg). Despite being treated with higher doses of inhaled corticosteroids (median dose 1773 microg) and for a third of the severe asthmatics also being treated with regular, oral-steroid therapy (median daily dose 19 mg), the subjects with severe asthma met the inclusion criteria. The criteria required subjects to have undergone at least one asthma exacerbation in the past year requiring oral steroid treatment. Females dominated the severe asthma group (female/male ratio 4.4:1 versus 1.6:1 in the controlled asthmatics), and compared with controlled asthmatics, they had a predominantly neutrophilic inflammation (sputum neutrophils, 36 versus 28%) and evidence of ongoing mediator release but less atopy. From these findings and other physiological and clinical data reported in this paper, it is suggested that severe asthma might be a different form of asthma rather than an increase in asthma symptoms. The findings prompt for longitudinal studies and interventions to define the mechanisms in severe asthma. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Epidemiologia delle broncopneumopatie e di altre malattie croniche non comunicabili (ME.P01.014.001) (Modulo)

Autore CNR

• FABIO CIBELLA (Persona)
• GIUSEPPINA CUTTITTA (Persona)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Epidemiologia delle broncopneumopatie e di altre malattie croniche non comunicabili (ME.P01.014.001) (Modulo)

Autore CNR di

• GIUSEPPINA CUTTITTA (Persona)
• FABIO CIBELLA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?European respiratory journal (Rivista)