Clinical and biological heterogeneity in children with moderate asthma. (Articolo in rivista)

Type
Label
  • Clinical and biological heterogeneity in children with moderate asthma. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • La Grutta S, Gagliardo R, Mirabella F, Pajno GB, Bonsignore G, Bousquet J, Bellia V, Vignola AM. (2003)
    Clinical and biological heterogeneity in children with moderate asthma.
    in American journal of respiratory and critical care medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • La Grutta S, Gagliardo R, Mirabella F, Pajno GB, Bonsignore G, Bousquet J, Bellia V, Vignola AM. (literal)
Pagina inizio
  • 1490 (literal)
Pagina fine
  • 1495 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 167 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Impact Factor: 5.956 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Questo studio dimostra la streta correlazione fra alcuni biomarcatori (GM-CSF, IL-8) e aspetti clinici dell'asma su una popolazione pediatrica.Detti marcatori si propongono pertanto come utili strumenti diagnostici e clinici per il monitoraggio dell'asma. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • La Grutta S: Azienda Ospedaliera ad alta specializzazione Civico-G.Di Cristina-Maurizio Ascoli. Mirabella F:titolare assegno ricerca IBIM-CNR, Bousquet J: INSERM-Montpellier-Francia.Vignola AM - Istituto di Medicina Generale e Pneumologia - Università di Palermo - Responsabile Sezione IFC-IBIM-CNR (literal)
Titolo
  • Clinical and biological heterogeneity in children with moderate asthma. (literal)
Abstract
  • To evaluate the relationship between inflammatory markers and severity of asthma in children, the amount of interleukin-8 (IL-8) and granulocyte/macrophage colony-stimulating factor (GM-CSF) released by peripheral blood mononuclear cells, exhaled nitric oxide (FE NO) levels, p65 nuclear factor-kappaB subunit, and phosphorylated IkBalpha expression by peripheral blood mononuclear cells were assessed in six control subjects, 12 steroid-naives subjects with intermittent asthma, and 17 children with moderate asthma. To investigate their predictive value, biomarker levels were correlated with the number of exacerbations during a 18-month follow-up period. We found that GM-CSF release was higher in moderate and intermittent asthmatics than in control subjects, whereas IL-8 release was higher in moderate than in intermittent asthmatics and control subjects. FE NO levels were similar among study groups. In moderate asthmatics, IL-8, GM-CSF, and FE NO significantly correlated with the exacerbation numbers. Moreover, p65 and phosphorylated IkBalpha levels were greater in moderate than in intermittent asthmatics and control subjects. According to GM-CSF, IL-8, and FE NO levels, two distinct subgroups of moderate asthmatics (low and high producers) were identified. High producers experienced more exacerbations than low producers. This study shows ongoing inflammation associated with biological and clinical heterogeneity in moderate asthmatics despite regular treatment and proposes that large prospective studies confirm the importance of biomarkers to assess inflammation and asthma control in children with asthma. (literal)
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