Characterization of Lung gamma/delta T Cells Following Intranasal Infection with Mycobacterium Bovis Bacillus Calmette-Guérin (Articolo in rivista)

Type
Label
  • Characterization of Lung gamma/delta T Cells Following Intranasal Infection with Mycobacterium Bovis Bacillus Calmette-Guérin (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Dieli F., Ivanyi J., Marsh P., Williams A., Naylor I., Sireci G., Caccamo N., Di Sano C., and Salerno A. (2003)
    Characterization of Lung gamma/delta T Cells Following Intranasal Infection with Mycobacterium Bovis Bacillus Calmette-Guérin
    in The Journal of immunology (1950)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Dieli F., Ivanyi J., Marsh P., Williams A., Naylor I., Sireci G., Caccamo N., Di Sano C., and Salerno A. (literal)
Pagina inizio
  • 463 (literal)
Pagina fine
  • 469 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 170 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Impact Factor: 7.650 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Tale studio sperimentale è volto all’analisi dei meccanismi di base della risposta immunitaria mucosale e della memoria, con particolare riguardo al coinvolgimento dei linfociti T gamma/delta (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biopathology, University of Palermo, Palermo, Italy; +Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba, Japan; ?La Jolla Institute for Allergy and Immunology, San Diego, CA 92121; §King's College London at Guy's Dental and Medical School, London, United Kingdom; ¶Laboratory of Bacteriology and Clinical Mycology, National Institute of Health, Rome, Italy; and ?Institute of Advanced Diagnostic Methodologies, National Research Council, Palermo, Italy (literal)
Titolo
  • Characterization of Lung gamma/delta T Cells Following Intranasal Infection with Mycobacterium Bovis Bacillus Calmette-Guérin (literal)
Abstract
  • The lungs are considered to have an impaired capacity to contain infection by pathogenic mycobacteria, even in the presence of effective systemic immunity. In an attempt to understand the underlying cellular mechanisms, we characterized the gammadelta T cell population following intranasal infection with Mycobacterium bovis bacillus Calmette-Guerin (BCG). The peak of gammadelta T cell expansion at 7 days postinfection preceded the 30 day peak of alphabeta T cell expansion and bacterial count. The expanded population of gammadelta T cells in the lungs of BCG-infected mice represents an expansion of the resident Vgamma2 T cell subset as well as an influx of Vgamma1 and of four different Vdelta gene-bearing T cell subsets. The gammadelta T cells in the lungs of BCG-infected mice secreted IFN-gamma following in vitro stimulation with ionomycin and PMA and were cytotoxic against BCG-infected peritoneal macrophages as well as against the uninfected J774 macrophage cell line. The cytotoxicity was selectively blocked by anti-gammadelta TCR mAb and strontium ions, suggesting a granule-exocytosis killing pathway. Depletion of gammadelta T cells by injection of specific mAb had no effect on the subsequent developing CD4 T cell response in the lungs of BCG-infected mice, but significantly reduced cytotoxic activity and IFN-gamma production by lung CD8 T cells. Thus, gammadelta T cells in the lungs might help to control mycobacterial infection in the period between innate and classical adaptive immunity and may also play an important regulatory role in the subsequent onset of alphabeta T lymphocytes. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it