http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11961
Non-specific bronchial hyper-responsiveness in children with allergic rhinitis: (Articolo in rivista)
- Type
- Label
- Non-specific bronchial hyper-responsiveness in children with allergic rhinitis: (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
Cuttitta G, Cibella F, La Grutta S, Hopps MR, Bucchieri S, Passalacqua G, (2003)
Non-specific bronchial hyper-responsiveness in children with allergic rhinitis:
in Pediatric allergy and immunology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cuttitta G, Cibella F, La Grutta S, Hopps MR, Bucchieri S, Passalacqua G, (literal)
- Pagina inizio
- Pagina fine
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- Rivista
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- PubMe (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Consiglio Nazionale delle Ricerche, Istituto di Fisiopatologia Respiratoria, Palermo
Clinica Pneumologica dell'Università, Palermo
Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa University (literal)
- Titolo
- Non-specific bronchial hyper-responsiveness in children with allergic rhinitis: (literal)
- Abstract
- An increased prevalence of bronchial hyper-responsiveness (BHR) has been
demonstrated in children from a general population, and in non-asthmatic adults
with allergic rhinitis. Thus, also children with allergic rhinitis are expected
to be at higher risk of BHR. We evaluated the prevalence of BHR in a sample of
non-asthmatic children with allergic rhinitis by means of the methacholine (Mch)
bronchial challenge, and by monitorizing the airway patency using the daily peak
expiratory flow variability (PEFv). Fifty-one children (ranged 6-15 years of
age) with allergic rhinitis, ascertained by skin prick test to inhalant
allergens, underwent a 14-day peak expiratory flow monitoring, and a Mch
bronchial provocation challenge. Thirty healthy children matched for age, and
sex served as control group. Thirty-one children in the rhinitis group (61%),
and six (20%) in the control group were Mch+ (Mch provocative dose causing a 20%
fall of forced expiratory volume in 1 s respect to baseline <2250 microg,
equivalent to 11.50 micromol). In rhinitic children the PEFv did not
significantly differ between Mch+ and Mch- subjects, but the total serum
immunoglobulin E (IgE) were higher among Mch+. The persistent form of rhinitis
was significantly associated to Mch positivity. Non-asthmatic children with
allergic rhinitis displayed a high prevalence of BHR. The BHR was significantly
associated with persistent rhinitis and with higher total IgE levels.
Nevertheless, the spontaneous changes in airway patency, as expressed by PEFv,
were within normal limits both in Mch+ and Mch- children. (literal)
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