http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11957
Biologically Active ICAM-1 is Shed as Dimers by a Regulated Mechanism in the Inflamed Pleural Space (Articolo in rivista)
- Type
- Label
- Biologically Active ICAM-1 is Shed as Dimers by a Regulated Mechanism in the Inflamed Pleural Space (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1164/rccm.200207-654OC (literal)
- Alternative label
Melis MR, Pace E,Siena L, Spatafora M, Tipa A, Profita M, Bonanno A, Vignola A.M., Bonsignore G, Mody C.H. , Gjomarkaj M, (2003)
Biologically Active ICAM-1 is Shed as Dimers by a Regulated Mechanism in the Inflamed Pleural Space
in American journal of respiratory and critical care medicine
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Melis MR, Pace E,Siena L, Spatafora M, Tipa A, Profita M, Bonanno A, Vignola A.M., Bonsignore G, Mody C.H. , Gjomarkaj M, (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- Questo studio é stato condotto nel contesto di un programma di collaborazione con l'Università di Calgary - Canada ed é stato supportato da un Grant dell'Alberta Lung Association ottenuto da IBIM-Università di Calgary (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- Impact Factor: 5.956 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
- Lo studio dimostra la presenza della molecola di adesione ICAM-1 solubile nel liquido pleurico di soggetti con TBC e cancro del polmone ed identifica le modalità di produzione di detta molecola da parte di alcuni citotipi immunocompetenti residenti. Il macrofago pleurico, mediante la secrezione di TNF é in grado di modulare il rilascio di ICAM-1 da parte di detti elementi cellulari che rilasciano la molecola, in forma dimerica, dalla loro superficie. L'ICAM solubile in tal modo rilasciato inteferisce con il legame fra cellle tumorali e cellule LAK. (literal)
- Note
- ISI Web of Science (WOS) (literal)
- PubMe (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Respiratory Physiopathology, Italian National Research Council; Institute of General Medicine and Pneumology, University of
Palermo, Palermo, Italy; and Department of Microbiology and Infectious Diseases and Department of Internal Medicine, University of
Calgary, Calgary, Alberta, Canada (literal)
- Titolo
- Biologically Active ICAM-1 is Shed as Dimers by a Regulated Mechanism in the Inflamed Pleural Space (literal)
- Abstract
- ICAM-1 is an adhesion molecule that plays a crucial role in cell-cell interactions involved in the recruitment of cells and immune responses. Under some circumstances, ICAM-1 is found as a soluble protein that has the potential to influence the nature of immunoinflammatory responses. By examining cells and fluid from the pleural compartment of patients with cancer, tuberculosis and congestive heart failure, the cellular source, conformation, control, and biological activity of soluble ICAM-1 (sICAM-1) was investigated. The results suggest that dimeric sICAM-1 was released locally in the pleural compartment of tuberculous and malignant effusions. sICAM-1, was shed from preexpressed surface ICAM-1 rather than produced de novo, and both CD45-positive leukocytes and cytokeratin-positive epithelial and mesothelial cells expressed ICAM-1 suggesting multiple cellular sources for sICAM-1. The expression of sICAM-1 was regulated since pleural macrophages caused release of sICAM-1 via a TNF-a-dependent mechanism. The functional significance of sICAM-1 was demonstrated by showing that pleural sICAM-1 interfered with the conjugate formation between LAK cells and K562 cells, suggesting that pleural sICAM-1 plays an immunosuppressive role by inhibiting adhesion of cytotoxic lymphocytes and tumor cells. Thus, sICAM-1 is shed from the surface of cells in a regulated manner and has the potential to influence the immune response in the pleural space. (literal)
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