http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11815
Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation (Articolo in rivista)
- Type
- Label
- Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.ccr.2010.05.027 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bruno T; Desantis A; Bossi G; Di Agostino S; Sorino C; De Nicola F; Iezzi S; Franchitto A; Benassi B; Galanti S; La Rosa F; Floridi A; Bellacosa A; Passananti C; Blandino G; Fanciulli M. (literal)
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- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Laboratory B, Department of Therapeutic Programs Development;
Rome Oncogenomic Center, Regina Elena Cancer Institute, Via E. Chianesi 53, 00144 Rome, Italy;
Molecular Oncogenesis Laboratory, Department of Experimental Oncology;
Istituto di Biologia e Patologia Molecolare, CNR, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy;
Department of Experimental Medicine, University of L'Aquila, Via Vetoio Coppito 2, 67100 L'Aquila, Italy;
Genome Stability Group, Department of Environment and Primary Prevention, Istituto Superiore di Sanita` , Viale Regina Elena 299, 00161 Rome, Italy; (literal)
- Titolo
- Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation (literal)
- Abstract
- Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo. Notably, loss of Che-1 activates DNA damage checkpoint response and induces transactivation of p73. Therefore, these findings underline the important role that Che-1 has in survival of cells expressing mutant p53. (literal)
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- Autore CNR
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