Yeast lsm pro-apoptotic mutants show defects in S-phase entry and progression (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Yeast lsm pro-apoptotic mutants show defects in S-phase entry and progression (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Palermo V, Cundari E, Mangiapelo E, Falcone C, Mazzoni C (2010)
  Yeast lsm pro-apoptotic mutants show defects in S-phase entry and progression
  in Cell cycle (Georget. Tex.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Palermo V, Cundari E, Mangiapelo E, Falcone C, Mazzoni C (literal)

Pagina inizio

• 3991 (literal)

Pagina fine

• 3996 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• Cell cycle (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 19 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Pasteur Institute-Cenci Bolognetti Foundation, Department of Biology and Biotechnology Charles Darwin, University of Rome Sapienza, Piazzale Aldo Moro 5, Rome, Italy. (literal)

Titolo

• Yeast lsm pro-apoptotic mutants show defects in S-phase entry and progression (literal)

Abstract

• Expression of the histone genes is tightly coupled to rates of DNA synthesis in yeast and histone mRNAs are modulated both transcriptionally and post-transcriptionally. Trf4 and Trf5, poly(A) polymerases that mediates polyadenylation and consequent degradation and Rrp6, an exosome component, play a role in the regulation of histone mRNA levels. In this paper we show that in the mRNA degradation mutant Kllsm4?1, histone mRNAs are induced early in S phase and maintained at high levels all along the entire cell cycle due to a delay in exit from S phase and/or entry into M phase. The overexpression of the HIR1 gene (Histone transcriptional repressor), previously isolated as a multicopy suppressor of the apoptotic phenotypes observed in Kllsm4?1, can also restore the normal cycling of histone gene expression. We also found that low doses of hydroxyurea neutralize the onset of the apoptotic phenotypes in Kllsm4?1, as well in another mRNA decapping mutant (lsm1) and, in addition, increase the chronological lifespan in both strains, suggesting that an entry delay into the S phase can recover some cellular defects in decapping mutants. (literal)

Prodotto di

• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)
• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• ENRICO CUNDARI (Persona)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)

Autore CNR di

• ENRICO CUNDARI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cell cycle (Rivista)