The Aurora-A/TPX2 complex: A novel oncogenic holoenzyme? (Articolo in rivista)

Type
Label
  • The Aurora-A/TPX2 complex: A novel oncogenic holoenzyme? (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbcan.2010.08.001 (literal)
Alternative label
  • Asteriti IA, Rensen WM, Lindon C, Lavia P and Guarguaglini G (2010)
    The Aurora-A/TPX2 complex: A novel oncogenic holoenzyme?
    in Biochimica et biophysica acta, CR. Reviews on cancer
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Asteriti IA, Rensen WM, Lindon C, Lavia P and Guarguaglini G (literal)
Pagina inizio
  • 230 (literal)
Pagina fine
  • 239 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1806 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Molecular Biology and Pathology, CNR; University of Cambridge, Department of Genetics (literal)
Titolo
  • The Aurora-A/TPX2 complex: A novel oncogenic holoenzyme? (literal)
Abstract
  • The Aurora-A kinase regulates cell division by phosphorylating multiple downstream targets in the mitotic apparatus. Aurora-A is frequently overexpressed in tumor cells and it is therefore regarded as a novel candidate target in anti-cancer therapy. Its actual contribution to cell transformation, however, is not entirely clarified; furthermore, its transforming ability has been found to vary broadly depending on the systems and experimental conditions in which it was assayed. This variability suggests that Aurora-A overexpression requires the concomitant deregulation of partner factor(s) to fully elicit its oncogenic potential. Molecular and structural studies indicate that the full activation and correct mitotic localisation of Aurora-A require its interaction with the spindle regulator TPX2. In this review we propose a brief reappraisal of Aurora-A intrinsic oncogenic features. We then present literature screening data indicating that TPX2 is also overexpressed in many tumor types, and, furthermore, that Aurora-A and TPX2 are frequently co-overexpressed. We therefore propose that the association of Aurora-A and TPX2 gives rise to a novel functional unit with oncogenic properties. We also suggest that some of the roles that are conventionally attributed to Aurora-A in cell transformation and tumorigenesis could in fact be a consequence of the oncogenic activation of this unit. (literal)
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