Tuning acetylated chromatin with HAT inhibitors: a novel tool for therapy (Articolo in rivista)

Type
Label
  • Tuning acetylated chromatin with HAT inhibitors: a novel tool for therapy (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.4161/epi.5.2.10942 (literal)
Alternative label
  • Vernarecci S; Tosi F; Filetici P (2010)
    Tuning acetylated chromatin with HAT inhibitors: a novel tool for therapy
    in Epigenetics; Landes Bioscience, Austin (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Vernarecci S; Tosi F; Filetici P (literal)
Pagina inizio
  • 105 (literal)
Pagina fine
  • 111 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.landesbioscience.com/journals/epigenetics/article/10942/?nocache=1118814378# (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Biologia e Patologia Molecolari, CNR; Sapienza Università di Roma, Italy (literal)
Titolo
  • Tuning acetylated chromatin with HAT inhibitors: a novel tool for therapy (literal)
Abstract
  • Epigenetics, the heritable changes that do not involve DNA sequences, give dynamic propulsion to a static genome and modulate genome accessibility by acting through multiple layers of regula- tion, ultimately ending with a variable organization of chromatin. The main player in chromatin reprograming is the nucleosome, which modifies its associa- tion to DNA depending on a variety of post-translational modifications (PTMs) on histone tails. PTMs act directly on higher order chromatin structures and affect the degree of DNA wrap around the histone octamer and the interaction and/or sequential recruitment of chro- matin-associated proteins and transcrip- tion factors at defined regions.1 Recently genomic approaches revealed a far more complex epigenome involving key pro- teins of cell signaling. (literal)
Editore
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Editore di
Insieme di parole chiave di
data.CNR.it