Chemogenomic profiling of the cellular effects associated with histone H3 acetylation impairment by a quinoline-derived compound (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Chemogenomic profiling of the cellular effects associated with histone H3 acetylation impairment by a quinoline-derived compound (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ygeno.2010.08.005 (literal)

Alternative label

• Ruotolo R, Tosi F, Vernarecci S, Ballario P, Mai A, Filetici P, Ottonello S. (2010)
  Chemogenomic profiling of the cellular effects associated with histone H3 acetylation impairment by a quinoline-derived compound
  in Genomics (S. Diego Calif.); Academic Press Elsevier, Inc., New York (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ruotolo R, Tosi F, Vernarecci S, Ballario P, Mai A, Filetici P, Ottonello S. (literal)

Pagina inizio

• 272 (literal)

Pagina fine

• 280 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0888754310001801 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 96 (literal)

Rivista

• Genomics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)
• Google Scholar (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Università di Parma, Università La Sapienza, Istituto di Biologia e Patologia Molecolari, CNR. (literal)

Titolo

• Chemogenomic profiling of the cellular effects associated with histone H3 acetylation impairment by a quinoline-derived compound (literal)

Abstract

• We report the results of a chemogenomic profiling aimed to explore the mode of action of a quinolic analogue of the p300 histone acetyltransferase (HAT) inhibitor anacardic acid, named MC1626. This compound reduced histone H3 acetylation in a dose-dependent manner and the HATs Gcn5 and Rtt109, which specifically target H3 lysines, were the only ones that caused chemical-genetic synthetic sickness with MC1626 when mutated. Deletion of specific Gcn5 (e.g., Ada1) and Rtt109 (e.g., Asf1) multiprotein complex components also enhanced MC1626 sensitivity. In addition to N-terminal H3 lysines, MC1626 inhibits H3-K56 acetylation, a histone modification that, in yeast, is exclusively supported by Rtt109 and indirectly influences DNA integrity. Several DNA repair mutants were found to be sensitive to MC1626. Functional links between histone acetylation impairment by MC1626 and mitochondrion as well as cytoskeleton functionality were also revealed, thus extending the range of non-nuclear processes that are influenced by histone acetylation. (literal)

Editore

• Academic Press Elsevier, Inc. (Editore)

Prodotto di

• Struttura e funzione di Acidi nucleici e Cromatina. Epigenetica (SV.P14.009.001) (Modulo)
• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• PAOLA BALLARIO (Unità di personale esterno)
• FEDERICA TOSI (Persona)
• PATRIZIA FILETICI (Unità di personale interno)
• STEFANO VERNARECCI (Persona)

Insieme di parole chiave

• Keywords of "Chemogenomic profiling of the cellular effects associated with histone H3 acetylation impairment by a quinoline-derived compound" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Struttura e funzione di Acidi nucleici e Cromatina. Epigenetica (SV.P14.009.001) (Modulo)

Autore CNR di

• PATRIZIA FILETICI (Unità di personale interno)
• STEFANO VERNARECCI (Persona)
• PAOLA BALLARIO (Unità di personale esterno)
• FEDERICA TOSI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Genomics (Rivista)

Editore di

• Academic Press Elsevier, Inc. (Editore)

Insieme di parole chiave di

• Keywords of "Chemogenomic profiling of the cellular effects associated with histone H3 acetylation impairment by a quinoline-derived compound" (Insieme di parole chiave)