http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11794

Borate Minerals and RNA Stability (Articolo in rivista)

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Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Cossetti C. (1), Crestini C.(2) , Saladino R.(3) , Di Mauro E.(1) (2010)
Borate Minerals and RNA Stability
in Biopolymers (Print); MDPI AG, Basel (Swaziland)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Rivista

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

(1) Dipartimento di Genetica e Biologia Molecolare, Università di Roma, \"Sapienza\" Rome, Italy; E-Mail: crisprinkly@hotmail.it, ernesto.dimauro@uniroma1.it (2) Dipartimento di Scienze e Tecnologie Chimiche, Università \"Tor Vergata\" 00133 Rome, Italy; E-Mail: crestini@uniroma2.it (3) Dipartimento ABAC, Università della Tuscia, Viterbo, Italy; E-Mail: saladino@unitus.it (literal)

Titolo

Abstract

The abiotic origin of genetic polymers faces two major problems: a prebiotically plausible polymerization mechanism and the maintenance of their polymerized state outside a cellular environment. The stabilizing action of borate on ribose having been reported, we have explored the possibility that borate minerals stabilize RNA. We observe that borate itself does not stabilize RNA. The analysis of a large panel of minerals tested in various physical-chemical conditions shows that in general no protection on RNA backbone is exerted, with the interesting exception of ludwigite Mg2Fe3+BO5. Stability is a fundamental property of nucleic polymers and borate are abundant components of the planet. Hence the prebiotic interest of this analysis. (literal)

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