A translational signature for nucleosome positioning in vivo (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A translational signature for nucleosome positioning in vivo (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• Caserta M, Agricola E, Churcher M, Hiriart E, Verdone L, Di Mauro E, Travers A. (2009)
  A translational signature for nucleosome positioning in vivo
  in Nucleic acids research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Caserta M, Agricola E, Churcher M, Hiriart E, Verdone L, Di Mauro E, Travers A. (literal)

Pagina inizio

• 5309 (literal)

Pagina fine

• 5321 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 37 (literal)

Rivista

• Nucleic acids research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Fondazione Istituto Pasteur-Fondazione Cenci Bolognetti, c/o Dipartimento di Genetica e Biologia Molecolare, 2Istituto Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Universita` 'La Sapienza', 00185 Rome, Italy, 3MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK and 4Fondation Pierre-Gilles de Gennes de la Recherche, c/o LBPA, E´ cole Normale Supe´ rieure de Cachan, 94235 Cachan, France (literal)

Titolo

• A translational signature for nucleosome positioning in vivo (literal)

Abstract

• In vivo nucleosomes often occupy well-defined preferred positions on genomic DNA. An important question is to what extent these preferred positions are directly encoded by the DNA sequence itself. We derive here from in vivo positions, accurately mapped by partial micrococcal nuclease digestion, a translational positioning signal that identifies the approximate midpoint of DNA bound by a histone octamer. This midpoint is, on average, highly A/T rich (~73%) and, in particular, the dinucleotide TpA occurs preferentially at this and other outwardfacing minor grooves. We conclude that in this set of sequences the sequence code for DNA bending and nucleosome positioning differs from the other described sets and we suggest that the enrichment of AT-containing dinucleotides at the centre is required for local untwisting. We show that this signature is preferentially associated with nucleosomes flanking promoter regions and suggest that it contributes to the establishment of gene-specific nucleosome arrays. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Struttura e funzione di Acidi nucleici e Cromatina. Epigenetica (SV.P14.009.001) (Modulo)

Autore CNR

• MICAELA CASERTA (Persona)
• LOREDANA VERDONE (Unità di personale interno)
• ERNESTO DI MAURO (Unità di personale esterno)

Incoming links:

Autore CNR di

• ERNESTO DI MAURO (Unità di personale esterno)
• MICAELA CASERTA (Persona)
• LOREDANA VERDONE (Unità di personale interno)

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Struttura e funzione di Acidi nucleici e Cromatina. Epigenetica (SV.P14.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nucleic acids research (Rivista)