Nucleosome positioning – what do we really know? (Articolo in rivista)

Type
Label
  • Nucleosome positioning – what do we really know? (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Travers A, Caserta M, Churcher M, Hiriart E, and Di Mauro E. (2009)
    Nucleosome positioning – what do we really know?
    in Molecular bioSystems (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Travers A, Caserta M, Churcher M, Hiriart E, and Di Mauro E. (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK 2Fondation Pierre-Gilles de Gennes pour la Recherche, c/o LBPA, École Normale Supérieure de Cachan, 94235 Cachan France 3Fondazione Istituto Pasteur-Fondazione Cenci Bolognetti, c/o Dipartimento di Genetica e Biologia Molecolare Università 'La Sapienza', 00185 Rome, Italy 4Istituto Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche Università 'La Sapienza', 00185 Rome Italy (literal)
Titolo
  • Nucleosome positioning – what do we really know? (literal)
Abstract
  • The positioning of nucleosomes on the DNA of eukaryotic genomes is a major determinant of gene expression. In particular nucleosomes in close proximity to regulatory regions are often more precisely positioned in vivo than nucleosomes located elsewhere. In this article we compare data obtained from the most recent studies by a variety of techniques. We argue that the disparate conclusions in the literature could be a consequence of procedural differences sampling alternative arrays of nucleosomes on the same DNA sequence. Importantly, the ostensibly least invasive techniques identify differences between nucleosomes in the vicinity of transcription start sites in budding yeast and those positioned distally within the transcribed region. (literal)
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