Bombinins, antimicrobial peptides from Bombina species (Articolo in rivista)

  • Bombinins, antimicrobial peptides from Bombina species (Articolo in rivista) (literal)
  • 2009-01-01T00:00:00+01:00 (literal)
  • 10.1016/j.bbamem.2009.01.004 (literal)
Alternative label
  • Simmaco M; Kreil G; Barra D. (2009)
    Bombinins, antimicrobial peptides from Bombina species
    in Biochimica et biophysica acta. Biomembranes
  • Simmaco M; Kreil G; Barra D. (literal)
Pagina inizio
  • 1551 (literal)
Pagina fine
  • 1555 (literal)
  • 1788 (literal)
  • 5 (literal)
  • 8 (literal)
  • PubMe (literal)
  • Istituto Pasteur-Fondazione Cenci Bolognetti, CNR Istituto di Biologia e Patologia Molecolari, Dipartimento di Scienze Biochimiche \"A. Rossi Fanelli\", Azienda Ospedaliera S. Andrea, Università La Sapienza, I-00185 Rome, Italy; Institute of Physiology and Pathophysiology, Paracelsus Medical University, A-5020 Salzburg, Austria (literal)
  • Bombinins, antimicrobial peptides from Bombina species (literal)
  • The skin secretions of Bombina species contain peptides and small proteins with interesting biological roperties. These include bombesin, thyrotropin releasing hormone, BSTI and Bv8. In this review, the biosynthesis and antimicrobial activity of two groups of peptides, bombinins and bombinins H, are described. To date, these have only been found in Bombina skin. They are derived from common precursors containing ne or two bombinin copies at the amino and a single bombinin H at the carboxyl end. Bombinins are active against Gram-positive and Gram-negative bacteria and fungi but virtually inactive in haemolysis assays. Conversely, bombinins H have lower bactericidal activities but lyse erythrocytes. In the skin secretions, bombinins H are present in two sizes with either 20 or 17 amino acids. Moreover, they occur as epimers with either an L- or a D-amino acid at position 2. An enzyme catalyzing this inversion of chirality of an amino acid in peptide linkage has been isolated from Bombina skin secretions. In different tests, also with different stages of the life cycle of Leishmania parasites, the d-forms were found to be more active. Biophysical studies have yielded some insight into the different behaviours of the epimers in model membranes. (literal)
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