Control of cytochrome c oxidase activity by nitric oxide. (Articolo in rivista)

Type
Label
  • Control of cytochrome c oxidase activity by nitric oxide. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • Brunori M; Giuffrè A; Forte E; Mastronicola D; Barone MC; Sarti P. (2004)
    Control of cytochrome c oxidase activity by nitric oxide.
    in Biochimica et biophysica acta. Bioenergetics
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Brunori M; Giuffrè A; Forte E; Mastronicola D; Barone MC; Sarti P. (literal)
Pagina inizio
  • 365 (literal)
Pagina fine
  • 371 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1655 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biochemical Sciences and CNR Institute of Molecular Biology and Pathology, University of Rome ''La Sapienza'', Piazzale Aldo Moro 5, I-00185 Rome, Italy. (literal)
Titolo
  • Control of cytochrome c oxidase activity by nitric oxide. (literal)
Abstract
  • Over the past decade it was discovered that, over-and-above multiple regulatory functions, nitric oxide (NO) is responsible for the modulation of cell respiration by inhibiting cytochrome c oxidase (CcOX). As assessed at different integration levels (from the purified enzyme in detergent solution to intact cells), CcOX can react with NO following two alternative reaction pathways, both leading to an effective, fully reversible inhibition of respiration. A crucial finding is that the rate of electron flux through the respiratory chain controls the mechanism of inhibition by NO, leading to either a ''nitrosyl'' or a ''nitrite'' derivative. The two mechanisms can be discriminated on the basis of the differential photosensitivity of the inhibited state. Of relevance to cell pathophysiology, the pathway involving the nitrite derivative leads to oxidative degradation of NO, thereby protecting the cell from NO toxicity. The aim of this work is to review the information available on these two mechanisms of inhibition of respiration. (literal)
Prodotto di
Autore CNR

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