Differential reproductive efficiency associated with common apolipoprotein e alleles in postreproductive-aged subjects. (Articolo in rivista)

Type
Label
  • Differential reproductive efficiency associated with common apolipoprotein e alleles in postreproductive-aged subjects. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.fertnstert.2003.05.029 (literal)
Alternative label
  • Corbo RM; Scacchi R; Cresta M. (2004)
    Differential reproductive efficiency associated with common apolipoprotein e alleles in postreproductive-aged subjects.
    in Fertility and sterility
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Corbo RM; Scacchi R; Cresta M. (literal)
Pagina inizio
  • 104 (literal)
Pagina fine
  • 107 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-0347355230&partnerID=40&md5=73b41f2b1aacc37457200f654b5c1849 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 81 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CORBO Rosa Maria, Department of Biology and Biotechnology, Sapienza University, Rome, Italy SCACCHI Renato, CNR Institute of Molecular Biology and Pathology, Rome, Italy (literal)
Titolo
  • Differential reproductive efficiency associated with common apolipoprotein e alleles in postreproductive-aged subjects. (literal)
Abstract
  • Objective: To investigate the possible impact of apolipoprotein E (APOE) polymorphism on reproductive efficiency. Design: Population study. Setting: University Departments and a Laboratory of National Research Council. Patient(s): One hundred sixty healthy unrelated subjects of postreproductive age. Intervention(s): Peripheral blood collection and questionnaire administration. Main Outcome Measure(s): Apolipoprotein E genotypes were detected after PCR amplification and CfoI digestion; plasma total cholesterol was assayed. Result(s): The mean number of children of e*2 allele carriers (2.4) was lower than that of e*3/e*3 and e*4/e*3 subjects (3.9). The trend was similar (2.8 vs. 4.8) when the number of pregnancies was considered. Moreover, there was a clear inverse relationship between number of children and e*2-carrying genotype proportions (?2 for trend ? 6.3). Conversely, the e*3/e*3 genotype was associated with the highest number of children and pregnancies (3.9 and 4.9, respectively), and the e*4/e*3 genotype, with intermediate values (3.7 and 4.4). Carriers of e*2 allele also showed the lowest levels of total cholesterol. Conclusion(s): The e*2 allele seems to be associated with the lowest reproductive efficiency and the e*3 allele, with the highest. The different total cholesterol levels associated with APOE genotypes could have an effect on steroidogenesis and determine as a consequence the observed differential fertility. (literal)
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