http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11676
Omomyc expression in skin prevents Myc-induced papillomatosis. (Articolo in rivista)
- Type
- Label
- Omomyc expression in skin prevents Myc-induced papillomatosis. (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Soucek L, Nasi S, Evan G. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Soucek L, Evan G: UCSF, S. Francisco, USA
Nasi S: Istituto di Biologia e Patologia Molecolari, CNR (literal)
- Titolo
- Omomyc expression in skin prevents Myc-induced papillomatosis. (literal)
- Abstract
- Obligate sensitization to apoptosis provides a safeguard
mechanism against the oncogenic potential of Myc. Omomyc
is a mutant bHLHZip domain that sequesters Myc in
complexes that are unable to bind to the E box recognition
element and activate transcription but remain competent for
transcriptional repression. Omomyc has the peculiar properties
of reverting Myc-induced transformation of tissue culture
cells and enhancing Myc proapoptotic function. Thus,
Omomyc has the potential to act as a potent suppressor of
Myc-induced oncogenesis. To validate the therapeutic
potential of Omomyc in vivo, we targeted its expression to
the adult suprabasal epidermis of Inv-c-MycERTAM transgenic
mice which express a switchable form of the Myc protein in
suprabasal cells. Activation of Myc induces rapid epidermal
hyperplasia and papillomatosis. We show that Omomyc
inhibits such Myc-induced papillomatosis, potentiating Mycdependent
apoptosis in a tissue in which it is usually strongly
suppressed. Furthermore, Omomyc expression restores the
normal keratinocyte differentiation program and skin architecture,
both of which are otherwise disrupted by Myc
activation. These findings indicate that it is possible to
selectively enhance the intrinsic apoptotic pathway mediated
by Myc and so quell its oncogenic action. (literal)
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- Autore CNR
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