Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s10522-008-9143-9 (literal)

Alternative label

• Corbo RM; Ulizzi L; Piombo L; Scacchi R. (2008)
  Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility
  in Biogerontology (Dordrecht)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Corbo RM; Ulizzi L; Piombo L; Scacchi R. (literal)

Pagina inizio

• 317 (literal)

Pagina fine

• 323 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-50649123209&partnerID=40&md5=669eb6596e76bf423da71e6221ccd59e (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• Biogerontology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CORBO Rosa Maria, Department of Biology and Biotechnology, Sapienza University, Rome, Italy SCACCHI Renato, CNR Institute of Molecular Biology and Pathology, Rome, Italy (literal)

Titolo

• Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility (literal)

Abstract

• The present study investigated for a possible effect on fertility of four longevity candidate genes (ACE, PON1, PPAR-c, APOE) in order to determine whether they have a pleiotropic action at different life ages. The study population was 151 healthy unrelated subjects. Only PPAR-c and APOE showed an effect on fertility. The PPAR-c Pro/Ala genotype, which had showed an association with longevity only in men, was found associated only in men with having produced more children (6.1 ± 3.3) than the Pro/Pro genotype (3.3 ± 1.9; P = 0.001). APOE*2 allele, which has been consistently associated with longevity, was confirmed to be associated with the lowest fertility (P = 0.03). The logistic regression analysis indicated that APOE and PPAR-c polymorphisms may be considered independent determinants of reproductive efficiency. These data suggest that the APOE*2 allele follows the model of antagonist pleiotropy, while the PPAR-c Pro/Ala genotype seems to exert beneficial effects both early in life and in advanced age in a gender-specific way. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Basi molecolari ed impatto biologico della variabilità genetica e della plasticità genomica (SV.P13.006.001) (Modulo)

Autore CNR

• RENATO SCACCHI (Persona)
• Rosa Maria Corbo (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Basi molecolari ed impatto biologico della variabilità genetica e della plasticità genomica (SV.P13.006.001) (Modulo)

Autore CNR di

• RENATO SCACCHI (Persona)
• Rosa Maria Corbo (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biogerontology (Rivista)

Insieme di parole chiave di

• Keywords of "Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility" (Insieme di parole chiave)