The peroxisome proliferator-activated receptor gamma (PPAR-gamma2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians. (Articolo in rivista)

Type
Label
  • The peroxisome proliferator-activated receptor gamma (PPAR-gamma2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.brainres.2006.12.078 (literal)
Alternative label
  • Scacchi R; Pinto A; Gambina G; Rosano A; Corbo RM. (2007)
    The peroxisome proliferator-activated receptor gamma (PPAR-gamma2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians.
    in Brain research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Scacchi R; Pinto A; Gambina G; Rosano A; Corbo RM. (literal)
Pagina inizio
  • 1 (literal)
Pagina fine
  • 5 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-33847318631&partnerID=40&md5=b75618ddb5a9c33180167fa1278054f8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1139 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CORBO Rosa Maria, Department of Biology and Biotechnology, Sapienza University, Rome, Italy SCACCHI Renato, CNR Institute of Molecular Biology and Pathology, Rome, Italy (literal)
Titolo
  • The peroxisome proliferator-activated receptor gamma (PPAR-gamma2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians. (literal)
Abstract
  • Recent observations support the hypothesis that inflammatory processes at the brain level may contribute to the pathogenesis of Alzheimer's disease (AD). Peroxisome proliferatoractivated receptor gamma (PPAR-?) is involved in such processes, so we thought it interesting to study the Pro12Ala polymorphism in exon 2 of the gene in a sample of lateonset AD patients. We found that Ala genotypes were significantly overrepresented among octogenarian patients compared to controls (p=0.034). Using logistic regression we observed that carrying the Ala allele significantly increased by nearly two-fold the risk of developing AD in subjects 80 years or older (OR=1.98; 95% CI 1.03-3.80, p=0.04). Though this difference was borderline significant after correction for multiple comparisons, our results suggest a possible involvement of the PPAR-? gene in susceptibility to late-onset AD in octogenarians. (literal)
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