Association of estrogen receptor alpha (ESR1) PvuII and XbaI polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentrations (Articolo in rivista)

Type
Label
  • Association of estrogen receptor alpha (ESR1) PvuII and XbaI polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentrations (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1159/000093315 (literal)
Alternative label
  • Corbo RM; Gambina G; Ruggeri M; Scacchi R (2006)
    Association of estrogen receptor alpha (ESR1) PvuII and XbaI polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentrations
    in Dementia and geriatric cognitive disorders
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Corbo RM; Gambina G; Ruggeri M; Scacchi R (literal)
Pagina inizio
  • 67 (literal)
Pagina fine
  • 72 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CORBO Rosa Maria, Department of Biology and Biotechnology, Sapienza University, Rome, Italy SCACCHI Renato, CNR Institute of Molecular Biology and Pathology, Rome, Italy (literal)
Titolo
  • Association of estrogen receptor alpha (ESR1) PvuII and XbaI polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentrations (literal)
Abstract
  • Background: Many studies have shown that estrogen replacement therapy may improve cognitive function in women and reduce the risk of Alzheimer's disease ( AD). Because most of the estrogen neuroprotective effect is mediated by receptors, we studied the associations between estrogen receptor alpha (ESR1) polymorphisms (Pvu II and Xba I) and AD, and their interactions with apolipoprotein E ( APOE) polymorphism and plasma levels. Methods: ESR1 genotypes and APOE plasma concentrations were determined in a sample of AD patients and controls. Results: ESR1 PP and XX genotypes were associated with an increased risk for AD only in males ( OR = 3.6, 95% CI = 1.2 - 10.9) and conferred a relevant additional risk of AD to subjects also carrying APOE e* 4 allele ( OR = 13.3, 95% CI = 1.7 - 103.6). Mean APOE concentrations were lower in AD patients; the lowest levels were observed in male patients carrying PP and/or XX genotypes ( p = 0.006) and in patients carrying PP and/or XX genotypes together with the e* 4 allele ( p = 0.003). In AD women, ESR1 PP and XX genotypes were also associated with lower MMSE values ( p = 0.0007). Conclusion: The present data suggest that the involvement of ESR1 polymorphisms in AD onset is mediated by the regulation of apoE expression. ESR1 polymorphisms are also associated with a faster cognitive decline in the women AD patients. Copyright (C) 2006 S. Karger AG, Basel. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it