Duplication, divergence and formation of novel protein topologies. (Articolo in rivista)

Type
Label
  • Duplication, divergence and formation of novel protein topologies. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Vogel C; Morea V (2006)
    Duplication, divergence and formation of novel protein topologies.
    in BioEssays
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Vogel C; Morea V (literal)
Pagina inizio
  • 973 (literal)
Pagina fine
  • 978 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 28 (literal)
Rivista
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute for Cellular and Molecular Biology, University of Texas at Austin, TX; CNR, Institute of Molecular Biology and Pathology, c/o Department of Biochemical Sciences, University La Sapienza, Rome, Italy. (literal)
Titolo
  • Duplication, divergence and formation of novel protein topologies. (literal)
Abstract
  • The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work(1) explored one possible underlying mechanism called permutation-by-duplication, which produces special forms of motif rearrangements called circular permutations. Permutation-by-duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins(1) and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence. (literal)
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