Cell death, proliferation and repair in human myocarditis responding to immunosuppressive therapy. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Cell death, proliferation and repair in human myocarditis responding to immunosuppressive therapy. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Andrea Frustaci; Cristina Chimenti; Maurizio Pieroni; Luisa Salvatori; Emanuela Morgante; Patrizio Sale; Elisabetta Ferretti; Elisa Petrangeli; Alberto Gulino; Matteo Antonio Russo. (2006)
  Cell death, proliferation and repair in human myocarditis responding to immunosuppressive therapy.
  in Modern pathology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Andrea Frustaci; Cristina Chimenti; Maurizio Pieroni; Luisa Salvatori; Emanuela Morgante; Patrizio Sale; Elisabetta Ferretti; Elisa Petrangeli; Alberto Gulino; Matteo Antonio Russo. (literal)

Pagina inizio

• 755 (literal)

Pagina fine

• 765 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 19 (literal)

Rivista

• Modern pathology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento \"Cuore e Grossi Vasi, Attilio Reale,\" Sapienza Università di Roma, Roma - IRCCS Istituto Nazionale per le Malattie Infettive , Lazzaro Spallanzani, Roma; Dipartimento \"Cuore e Grossi Vasi, Attilio Reale,\" Sapienza Università di Roma, Roma - IRCCS Istituto Nazionale per le Malattie Infettive , Lazzaro Spallanzani, Roma; IRCCS Ospedale Multimedica, Milano; Dipartimento Medicina Sperimentale e Patologia, Sapienza Università di Roma, Roma; Dipartimento Medicina Sperimentale e Patologia, Sapienza Università di Roma, Roma; Dipartimento Medicina Sperimentale e Patologia, Sapienza Università di Roma, Roma - IRCCS San Raffaele Pisana, Roma; Dipartimento Medicina Sperimentale e Patologia, Sapienza Università di Roma, Roma; Dipartimento Medicina Sperimentale e Patologia, Sapienza Università di Roma, Roma- IRCCS San Raffaele Pisana, Roma; Dipartimento Medicina Sperimentale e Patologia, Sapienza Università di Roma, Roma; Dipartimento Medicina Sperimentale e Patologia, Sapienza Università di Roma, Roma - IRCCS San Raffaele Pisana, Roma. (literal)

Titolo

• Cell death, proliferation and repair in human myocarditis responding to immunosuppressive therapy. (literal)

Abstract

• In this study, we evaluate cell death, proliferation and repair in left ventricular endomyocardial biopsies from 20 patients with active lymphocytic myocarditis worsening or recovering from cardiac dysfunction after 6-months immunosuppression. Apoptosis and necrosis were assessed by in situ ligation of hairpin probes, proliferation by Ki67 and MCM5 labelling of myocytes, repair by electron microscopy, morphometric study of percent myofibrillar area and real-time polymerase chain reaction of alpha-and beta-Myosin Heavy Chain (MHC). Apoptosis and necrosis decreased in post- vs pretreatment biopsies by 85 and 62%, respectively in responders, while increased by 42 and 46% in nonresponders. Ki67 and MCM5-positive myocytes were higher vs controls at baseline and increased by 43 and 38% at follow-up in responders and by 75 and 63% in nonresponders. Myofibrillar area reduced in pretreatment samples, increased by 33% at follow-up in responders, correlated with percent enhancement of ejection fraction and was associated with increased alpha-MHC expression and alpha/beta-MHC ratio. In follow-up biopsies of nonresponders, myofibrillar area diminished by 36% and correlated with percent decrease of ejection fraction. Our results suggest that recovery of cardiac function in myocarditis responding to immunosuppression is associated with inhibition of cell death, activation of cell proliferation and with newly synthesized contractile material. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Controllo di proliferazione, differenziamento e morte cellulare (SV.P15.010.001) (Modulo)

Autore CNR

• LUISA SALVATORI (Persona)
• ELISA PETRANGELI (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Controllo di proliferazione, differenziamento e morte cellulare (SV.P15.010.001) (Modulo)

Autore CNR di

• ELISA PETRANGELI (Unità di personale esterno)
• LUISA SALVATORI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Modern pathology (Rivista)