A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bcp.2005.06.013, (literal)

Alternative label

• Ornaghi P, Rotili D, Sbardella G, Mai A, Filetici P. (2005)
  A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast.
  in Biochemical pharmacology; Editore: Elsevier, Oxford (Regno Unito)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ornaghi P, Rotili D, Sbardella G, Mai A, Filetici P. (literal)

Pagina inizio

• 911 (literal)

Pagina fine

• 917 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0006295205004181 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 70 (literal)

Rivista

• Biochemical pharmacology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• Google Scholar (literal)
• ISI Web of Science (WOS) (literal)
• PubMed (literal)
• Scopus (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Sapienza Università di Roma, Istituto di Biologia e Patologia Molecolari (literal)

Titolo

• A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast. (literal)

Abstract

• Histone acetyltransferases are key chromatin regulators responsible for transcriptional activation and cell cycle progression. We propose a simple yeast-based assay to determine the specificity and targets of novel Gcn5p inhibitors. Here, we report the finding of a novel, small molecule, MC1626, which is able to inhibit yeast cell growth, Gcn5p-dependent gene transcription and acetylation of the histone H3 N-terminal tail in vivo. Because HATs misregulation is invariably associated with human diseases, the identification of MC1626 as a novel cell-permeable Gcn5p inhibitor suggests that it may be a very useful starting tool for the further development of new molecules to be applied to expression profiling of genes regulated by histone H3 acetylation. In addition, our results demonstrate that MC1626 is a Gcn5p-dependent yeast growth inhibitor. (literal)

Editore

• Editore: Elsevier (Editore)

Prodotto di

• Struttura e funzione di Acidi nucleici e Cromatina. Epigenetica (SV.P14.009.001) (Modulo)
• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• PATRIZIA FILETICI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Struttura e funzione di Acidi nucleici e Cromatina. Epigenetica (SV.P14.009.001) (Modulo)

Autore CNR di

• PATRIZIA FILETICI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biochemical pharmacology (Rivista)

Editore di

• Editore: Elsevier (Editore)

Insieme di parole chiave di

• Parole chiave di "A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast." (Insieme di parole chiave)