Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditions. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditions. (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Verdone L. 1, Wu J. 2, Van Riper K. 3, Kacherovsky N. 3, Vogelauer M. 2, Young E.T. 3, Grunstein M. 2, Di Mauro E. 1, 4, Caserta M. 4 (2002)
  Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditions.
  in EMBO journal (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Verdone L. 1, Wu J. 2, Van Riper K. 3, Kacherovsky N. 3, Vogelauer M. 2, Young E.T. 3, Grunstein M. 2, Di Mauro E. 1, 4, Caserta M. 4 (literal)

Pagina inizio

• 1101 (literal)

Pagina fine

• 1111 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• This work presents the first in vivo demonstration of a chromatin structural modification induced by changes in the levels of histone acetylation. The paper is published in a highly valued international journal with an impact factor of 10.698. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• EMBO journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• E. Di Mauro è a disposizione dell'IBPM (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• In this work we report that in vivo increased acetylation of the repressed Saccharomyces cerevisiae ADH2 promoter chromatin, as obtained by disrupting the genes for the two deacetylases HDA1 and RPD3, destabilizes the structure of the TATA box-containing nucleosome. This acetylation-dependent chromatin remodeling is not sufficient to allow the binding of the TATA box-binding protein, but facilitates the recruitment of the transcriptional activator Adr1 and induces faster kinetics of mRNA accumulation when the cells are shifted to derepressing conditions. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 UNI Sapienza (Istituto Pasteur - Fondazione Cenci-Bolognetti), 2 UNI California (Department of Biological Chemistry, UCLA School of Medicine and Molecular Biology Institute), 3 UNI Washington (Department of Biochemistry), 4 CNR (C.S. sugli Acidi Nucleici). (literal)

Titolo

• Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditions. (literal)

Abstract

• We report that in vivo increased acetylation of the repressed Saccharomyces cerevisiae ADH2 promoter chromatin, as obtained by disrupting the genes for the two deacetylases HDA1 and RPD3, destabilizes the structure of the TATA box-containing nucleosome. This acetylation-dependent chromatin remodeling is not sufficient to allow the binding of the TATA box-binding protein, but facilitates the recruitment of the transcriptional activator Adr1 and induces faster kinetics of mRNA accumulation when the cells are shifted to derepressing conditions. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• LOREDANA VERDONE (Unità di personale interno)
• MICAELA CASERTA (Persona)
• ERNESTO DI MAURO (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditions." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ERNESTO DI MAURO (Unità di personale esterno)
• MICAELA CASERTA (Persona)
• LOREDANA VERDONE (Unità di personale interno)

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• EMBO journal (Rivista)

Insieme di parole chiave di

• Keywords of "Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditions." (Insieme di parole chiave)