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Evidence for the host contribution in the definition of preferential insertion sites of the elements of Bari 1 transposon family in Drosophila melanogaster. (Articolo in rivista)

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Evidence for the host contribution in the definition of preferential insertion sites of the elements of Bari 1 transposon family in Drosophila melanogaster. (Articolo in rivista) (literal)

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Soriano S. 1, Fortunati D. 1, Junakovic N. 1 (2002)
Evidence for the host contribution in the definition of preferential insertion sites of the elements of Bari 1 transposon family in Drosophila melanogaster.
in Journal of molecular evolution
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Insertional specificity is believed to be an adaptation of transposable elements under the pressure to avoid inflicting unbearable damage to their host. This is because the elements, which are obligate parasites, would commit suicide by estinguishing their host. This report is among the first ones that provides evidence for a host role in insertional specificity representing an aditional line of defence aginst rogue elements. The paper is published in a peer-reviewed international journal with an impact factor of 3.041. (literal)

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One of the key features of the transposon-host interaction is believed to consist of a series of lines of defence that have evolved to limit the potentially deleterious effects of insertional mutation. In this paper evidence is described suggesting that one of those lines of defence consists of opening the chromatin at genetically neutral sites where elements insert preferentially. This particular form of containment would be especially important at times following a new horizontal transfers of transposable elements. (literal)

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Titolo

Evidence for the host contribution in the definition of preferential insertion sites of the elements of Bari 1 transposon family in Drosophila melanogaster. (literal)

Abstract

A follow-up over 83 generations has been carried out, by the Southern blotting technique, of a Drosophila stock which is unstable in the location of Bari 1 elements. The persistent intrastock polymorphism detected is largely amenable to insertion/excision equilibria at 36 genomic sites that form a gradient in occupancy. In a closely related stock, Bari 1 elements are stable and exhibit a substantially different genomic distribution. These results suggest that in Drosophila preferential insertion sites may be defined with the contribution of host factors, although alternative interpretations are also possible. The relevance to the mechanism(s) that contains the potentially deleterious effects of transposition is discussed. (literal)

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