NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0014-5793(01)03227-6 (literal)

Alternative label

• Mandolesi G. 1, Gargano S. 1, Pennuto M. 1, Illi B. 1, Molfetta R. 1, Soucek L. 1, Mosca L. 1, Levi A. 2, Jucker R. 1, Nasi S. 1 (2002)
  NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction
  in FEBS letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mandolesi G. 1, Gargano S. 1, Pennuto M. 1, Illi B. 1, Molfetta R. 1, Soucek L. 1, Mosca L. 1, Levi A. 2, Jucker R. 1, Nasi S. 1 (literal)

Pagina inizio

• 50 (literal)

Pagina fine

• 56 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• FEBS Lett. 2002 Jan 2;510(1-2):50-6. We describe the components of a critical protein complex for modulating gene expression in neuronal cells. The paper is published in a peer-reviewed international journal with an impact factor of 3.912. Impact factor (anno 2002) 3.912 Classificazione SCImago nelle subject categories Molecular Biology, Cell Biology, Biochemistry: Q1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 510 (literal)

Rivista

• FEBS letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1-2 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Neurotrophins support neuronal survival, development, and plasticity through processes requiring gene expression. We studied how vgf target gene transcription is mediated by a critical promoter region containing E box, CCAAT and CRE sites. The p300 acetylase was present in two distinct protein complexes bound to this region. One complex, containing HEB (ubiquitary bHLH), bound the promoter in non neuronal cells and was involved in repressing vgf expression. Neurotrophin dependent transcription was mediated by the second complex, specific for neuronal cells, which included CREB and Mash1 (neurospecific bHLH), bound the CCAAT motif, and was target of neurotrophin signalling. The interaction, mediated by p300, of different transcription factors may add specificity to the neurotrophin response. (literal)

Note

• ISI Web of Science (WOS) (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 CNR (C.S. sugli Acidi Nucleici), 2 CNR (Istituto di Neurobiologia). (literal)

Titolo

• NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction (literal)

Abstract

• Neurotrophins support neuronal survival, development, and plasticity through processes requiring gene expression. We studied how vgf target gene transcription is mediated by a critical promoter region containing E box, CCAAT and CRE sites. The p300 acetylase was present in two distinct protein complexes bound to this region. One complex, containing HEB (ubiquitary bHLH), bound the promoter in non neuronal cells and was involved in repressing vgf expression. Neurotrophin dependent transcription was mediated by the second complex, specific for neuronal cells, which included CREB and Mash1 (neurospecific bHLH), bound the CCAAT motif, and was target of neurotrophin signalling. The interaction, mediated by p300, of different transcription factors may add specificity to the neurotrophin response. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• BARBARA ILLI (Unità di personale interno)
• SERGIO NASI (Persona)
• RICHARD PHILIPPE MAR JUCKER (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR di

• SERGIO NASI (Persona)
• RICHARD PHILIPPE MAR JUCKER (Unità di personale interno)
• BARBARA ILLI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• FEBS letters (Rivista)

Insieme di parole chiave di

• Parole chiave di "NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction" (Insieme di parole chiave)