Biomimetic structure for implants and tissue engineering (Comunicazione a convegno)

Type
Label
  • Biomimetic structure for implants and tissue engineering (Comunicazione a convegno) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • L. Ambrosio (2004)
    Biomimetic structure for implants and tissue engineering
    in Internationa Conference on Biomaterials and Tissue Engineering, Kuala Lampur
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • L. Ambrosio (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • , the present research is aimed to study in a systematic and quantitative manner the effect of the 3-D scaffold structure and stiffness upon cellular growth and remodelling. Composite scaffolds made by Polycaprolactone and Hydroxyapatite are prepared for bone tissue reconstruction to modulate mechanical properties and cell interaction. Replication of the structure and the functions of the extracellular matrix in vitro is performed by forming a semi-Interpenetrated Polymer Network (s-IPN) between Collagen type I and Hyaluronic acid (HL). The rheological behaviour of the semi-IPN collagen/HL have been analysed to evaluate the effect of Hyaluronic Acid and collagen in the composite gel. Cell viability, growth and morphology of cells were assessed with different cell line embedded in 3D gels of collagen with variable physical properties while maintaining a constant chemical environment. As results it was clear that on all these substrata cells were observed to adhere, loco mote, and divide and that the rate of movement depends on the nature of the surrounding gel. (literal)
Titolo
  • Biomimetic structure for implants and tissue engineering (literal)
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