Bio-inspired structures for implants and tissue engineering (Comunicazione a convegno)

Type
Label
  • Bio-inspired structures for implants and tissue engineering (Comunicazione a convegno) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • L. Ambrosio, S.Battista, A. Borzacchiello, C.Borselli, F Causa, R. De Santis, P. Netti, S. Zeppetelli (2004)
    Bio-inspired structures for implants and tissue engineering
    in International Conference on Biomaterials and Medical Devices, Bucharest
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • L. Ambrosio, S.Battista, A. Borzacchiello, C.Borselli, F Causa, R. De Santis, P. Netti, S. Zeppetelli (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • One of the principal goals of the biomedical engineering is to design of biomaterials capable to replace, substitute or repair natural tissues. In order to satisfy all the complex requirement, composites polymer based materials technology can be implemented to designed an appropriate scaffolds. Composite scaffolds made by Polycaprolactone and Hydroxyapatite are prepared for bone tissue reconstruction to modulate mechanical properties and cell interaction. Replication of the structure and the functions of the extracellular matrix in vitro is performed by forming a semi-Interpenetrated Polymer Network (s-IPN) between Collagen type I and Hyaluronic acid (HL). The rheological behaviour of the semi-IPN Collagen/HL have been analysed to evaluate the effect of Hyaluronic Acid and collagen in the composite gel. Cell viability, growth and morphology of cells were assessed with different cell line embedded in 3D gels of collagen with variable physical properties while maintaining a constant chemical environment. The results indicate the possibility to control cell proliferation by modulating the physical/chemical properties of the material. On collagen gels cells were observed to adhere and proliferate and as results an optimum value of the gel’s stiffness/concentration that promote cell activity, was identified. The collagen/hyaluronic acid composite showed appropriate rheological properties to be used as gel for cell carrier. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Università di Napoli Federico II (literal)
Titolo
  • Bio-inspired structures for implants and tissue engineering (literal)
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