In vitro and in vivo behaviors of injectable composite bone substitute¡¨ (Abstract/Poster in atti di convegno)

Type
Label
  • In vitro and in vivo behaviors of injectable composite bone substitute¡¨ (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • V. Sanginario, V. Guarino P.A, Netti, S. Zeppetelli, L. Ambrosio, P. Torricelli, M. Fini, R. Giardino, M.P.Ginebra, J.A.Planell (2006)
    In vitro and in vivo behaviors of injectable composite bone substitute¡¨
    in 1st Chinese-European Symposium on Biomaterials in Regenerative Medicine, Suzhou, China
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • V. Sanginario, V. Guarino P.A, Netti, S. Zeppetelli, L. Ambrosio, P. Torricelli, M. Fini, R. Giardino, M.P.Ginebra, J.A.Planell (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Calcium Phosphate are widely used as bone substitute in orthopaedic, reconstructive, and oral surgery because of their beneficial effect on bone healing. Among CPBC, in this work, ƒÑ-Tricalcium Phosphate (ƒÑ-TCP) has been choose and its properties can be optimized with the addition of an organic phase improving both mechanical and injectability behaviour. As organic phase an hydrogel has been used: Poly(VinylAlcohol) which is one of the most widely used for biomedical applications. The main characteristic of this hydrogel is its water solubility: in fact it is possible to obtain a ready to use system without using toxic substances, which will hard in a clinically acceptable period of time. The composite demonstrated enhanced mechanical properties than the cement alone. In vitro biocompatibility and cell interaction with Osteosarcoma cell line (U2OS) have been assessed. On the basis of ¡§in vitro¡¨ promising results, ¡§in vivo¡¨ test are have been by strictly following Italian and European Laws on animal use for experimental purposes. To evaluate bone in-growth in critical size defects created in the distal femur of rabbits and comparatively treated with H-Cem and H-Cem/PVA, bone healing rate will be measured at 4 and 12 weeks by means of histology and histomorphometry. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituti Ortopedici Rizzoli, Bologna Università di Napoli Federico II (literal)
Titolo
  • In vitro and in vivo behaviors of injectable composite bone substitute¡¨ (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Insieme di parole chiave di
data.CNR.it