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Matrix-bound angiogenic factors enhance the angiogenic response within 3D biopolymers (Abstract/Poster in atti di convegno)

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Matrix-bound angiogenic factors enhance the angiogenic response within 3D biopolymers (Abstract/Poster in atti di convegno) (literal)

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Borselli C, Oliviero O., Battista S., Ambrosio L., Netti P.A. (2005)
Matrix-bound angiogenic factors enhance the angiogenic response within 3D biopolymers
in 19th European Conference on Biomaterials, Sorrento
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To improve the angiogenic capability of engineered tissues, we investigated the role played by the interaction between angiogenic factors and extracellular matrix components in enhancing the vascular morphogenic response in vitro. Several studies in the literature have shown that endothelial cells proliferation, migration and remodelling are influenced by the extracellular matrix (ECM) composition. Moreover, the extracellular matrix is also considered important both as a protecting reservoir of biologically active growth factors and as an enhancer of the receptor-binding affinity of growth factors. The aim of this work was to study how the angiogenic response can be modulated by the association of angiogenic factors such as VEGF within growth factor-binding matrices. The data show that the angiogenic response in vitro can be modulated by structural ECM components with different angiogenic factors binding affinity. The synergic cooperation observed between structural matrix components and angiogenic factors can be exploited to enhanc the angiogenic response within engineered tissues. (literal)

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