Mechanisms of Bone Regeneration Induced by Soybean-Based Biomaterials (Abstract/Poster in atti di convegno)

Type
Label
  • Mechanisms of Bone Regeneration Induced by Soybean-Based Biomaterials (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • M. Santin, C. Morris, G. Standen, V. Sanginario, L. Nicolais, L. Ambrosio, C. Gabbi, A. Merolli (2005)
    Mechanisms of Bone Regeneration Induced by Soybean-Based Biomaterials
    in 19th European Conference on Biomaterials, Sorrento
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M. Santin, C. Morris, G. Standen, V. Sanginario, L. Nicolais, L. Ambrosio, C. Gabbi, A. Merolli (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Bone regeneration after a pathological, traumatic or surgical insult follows the normal sequence of events typical of a wound healing process. After colonisation of the site of injury, osteoblasts synthesise in the surrounding environment components of the extracellular matrix. Collagen is the most important component as it forms the template upon which the calcium-phosphate mineralization of the bony tissue takes place. Matrix mineralization is dictated principally by the osteoblast ability to: (i) secrete calcium-binding proteins and matrix vesicles and (ii) synthesise alkaline phosphatase (ALP). However, in the case of critical-size bone defects, the cells are not able to regenerate completely the tissue unless a polymeric or ceramic scaffold is implanted. However, these materials have no bioactivity and suffer of limitations such as inadequate mechanical and resorption properties, pro-inflammatory action and relatively high commercial costs. Recently, a novel class of soybean-based biodegradable biomaterials (SB) has been developed which has shown an anti-inflammatory action as well as bone regeneration potential in vitro and in vivo. The present work clarifies the mechanism of action of SB on osteoblasts and shows their effects on bone regeneration and remodelling in vivo in a recognised animal model. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • University of Brighton, U.K. University of Parma Catholic Unoversity, Roma Università di Napoli Federico II (literal)
Titolo
  • Mechanisms of Bone Regeneration Induced by Soybean-Based Biomaterials (literal)
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