Manufacture Process Control and Cytotoxicity Evaluation of Soybean-Based Biomaterials (Abstract/Poster in atti di convegno)

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  • Manufacture Process Control and Cytotoxicity Evaluation of Soybean-Based Biomaterials (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • G. Standen, J. Salvage, C. Morris, V. Sanginario, L. Nicolais, L. Ambrosio, M. Santin (2005)
    Manufacture Process Control and Cytotoxicity Evaluation of Soybean-Based Biomaterials
    in 19th European Conference on Biomaterials, Sorrento
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • G. Standen, J. Salvage, C. Morris, V. Sanginario, L. Nicolais, L. Ambrosio, M. Santin (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • A new class of bioactive materials has been recently developed from soybeans. Unlike other works which have focused onto the preparation of biomaterials from soy protein. The main advantage of this approach is the retention of important components of the soy such as carbohydrates, isoflavones, and minerals. Indeed, it has been demonstrated that the unique combination of all the soy fractions confers to the soybean-based biomaterials (SB) an anti-inflammatory action and an osteoblast differentiation potential leading to the relatively rapid production of new mineralized bone in vitro and in vivo. However, to bring this new class of biomaterials from the research stage to the commercial production it is fundamental to control the production process, the quality control (QC) of both the raw materials and the final products as well as to prove their safety. De-fatting the material is a pre-requisite to achieve appropriate physico-chemical properties and avoiding putative cytotoxic effects of the soy oil. Similarly, controlling the batch-to-batch protein, carbohydrate and isoflavone during preparation is fundamental to ensuring the delivery of products with guaranteed clinical performances. The present study shows: (i) the optimization of the de-fatting process of the soy raw material, (ii) optimised QC processes, and (iii) the safety test of the SB and of some of its components, i.e. oil contaminants and genistein, abioactive soy isoflavone. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • University of Brighton, U.K. (literal)
Titolo
  • Manufacture Process Control and Cytotoxicity Evaluation of Soybean-Based Biomaterials (literal)
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