http://www.cnr.it/ontology/cnr/individuo/prodotto/ID113522

Novel bioactive scaffold by sintering biodegradable microspheres (Abstract/Poster in atti di convegno)

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Novel bioactive scaffold by sintering biodegradable microspheres (Abstract/Poster in atti di convegno) (literal)

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V.Coccoli, A.Luciani, V.Guarino, F.Causa, L.Ambrosio, P.A.Netti (2005)
Novel bioactive scaffold by sintering biodegradable microspheres
in 19th European Conference on Biomaterials, Sorrento
(literal)

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One of the most important challenges in tissue engineering bone substitute is the fabrication of suitable porous biodegradable scaffold. It has been shown that pore size distribution, shape and degree of interconnectivity as well as degradation rate are important parameters in controlling tissue regeneration process. Moreover, it has also been reported that an active scaffold for tissue engineering should enhance and guide the process regeneration through the sequestration and delivery of specific bioactive factors. In this work we have developed a novel scaffold obtained through the sintering of biodegradable microspheres made of poly å-caprolactone. 3D porous highly interconnected scaffolds are obtained through thermal and mechanical microspheres compaction. Pore size, degree of porosity and interconnectivity are thus controllable by microspheres dimension and processability. Furthermore, by sintering protein loaded microspheres, bioactive scaffold capable of sequestration and delivery of biological agent have been obtained. These novel matrices offer the possibility to modulate porosity, degradation rate, mechanical properties and spatial-temporal distribution of bioactive signals. (literal)

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