http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11340
Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels (Articolo in rivista)
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- Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
Fonsatti E, Altomonte M, Nicotra MR, Natali PG, Maio M. (2003)
Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels
in Oncogene (Basingstoke)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Fonsatti E, Altomonte M, Nicotra MR, Natali PG, Maio M. (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- ISI Web of Science (WOS) (literal)
- Titolo
- Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels (literal)
- Abstract
- Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory component of the transforming growth factor -beta receptor complex and is involved in vascular development and remodelling. Quantification of intratumoral microvessel
density by CD105 staining and of circulating soluble CD105 has been suggested to have prognostic significance in selected neoplasias. In addition, the potential usefulness of CD105 in tumor imaging and antiangiogenetic therapy has been well documented utilizing different animal models. (literal)
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