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Colonization of heterochromatic introns by transposable elements in Drosophila melanogaster (Articolo in rivista)

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Colonization of heterochromatic introns by transposable elements in Drosophila melanogaster (Articolo in rivista) (literal)

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Dimitri P., Junakovic N., Arca B. (2003)
Colonization of heterochromatic introns by transposable elements in Drosophila melanogaster
in Molecular biology and evolution
(literal)

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A paradigm shift is taking place in this field following the completion of the sequencing of numerous eukaryotic genomes, including the human one. The previous view of transposable elements as mere genomic parasites is turning obsolete following experimental evidence for their contribution to genes, regulatory sequences and genome structure. This paper adds one more item to such a list. The paper is published in a valued international journal with an impact factor of 6.050. (literal)

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The conceptual background to this paper is the relationship between transposable elements and their host. This is a broad subject which is primarily of evolutionary interest but has implications to human health as well because those events that in model systems are called insertional mutations, may give rise in humans to a variety of diseases such haemophylia, cancer and muscular dystrophy. (literal)

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Colonization of heterochromatic introns by transposable elements in Drosophila melanogaster (literal)

Abstract

As a further step toward understanding transposable element-host genome interactions, we investigated the molecular anatomy of introns from five heterochromatic and 22 euchromatic protein-coding genes of Drosophila melanogaster. A total of 79 kb of intronic sequences from heterochromatic genes and 355 kb of intronic sequences from euchromatic genes have been used in Blast searches against Drosophila transposable elements (TEs). The results show that TE-homologous sequences belonging to 19 different families represent about 50% of intronic DNA from heterochromatic genes. In contrast, only 0.1% of the euchromatic intron DNA exhibits homology to known TEs. Intraspecific and interspecific size polymorphisms of introns were found, which are likely to be associated with changes in TE-related sequences. Together, the enrichment in TEs and the apparent dynamic state of heterochromatic introns suggest that TEs contribute significantly to the evolution of genes located in heterochromatin. (literal)

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