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Integrin alpha3beta1 is an alternative cellular receptor for adenovirus serotype 5. (Articolo in rivista)

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Integrin alpha3beta1 is an alternative cellular receptor for adenovirus serotype 5. (Articolo in rivista) (literal)

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Salone B , Martina Y , Piersanti S , Cundari E , Cherubini G , Franqueville L , Failla CM , Boulanger P , Saggio I (2003)
Integrin alpha3beta1 is an alternative cellular receptor for adenovirus serotype 5.
in Journal of virology (Print)
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Salone B , Martina Y , Piersanti S , Cundari E , Cherubini G , Franqueville L , Failla CM , Boulanger P , Saggio I (literal)

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Integrin alpha3beta1 is an alternative cellular receptor for adenovirus serotype 5. (literal)

Abstract

Many adenovirus serotypes enter cells by high-affinity binding to the coxsackievirus-adenovirus receptor (CAR) and integrin-mediated internalization. In the present study, we analyzed the possible receptor function of alpha3beta1 for adenovirus serotype 5 (Ad5). We found that penton base and integrin alpha3beta1 could interact in vitro. In vivo, both Ad5-cell binding and virus-mediated transduction were inhibited in the presence of anti-alpha3 and anti-beta1 function-blocking antibodies, and this occurred in both CAR-positive and CAR-negative cell lines. Peptide library screenings and data from binding experiments with wild-type and mutant penton base proteins suggest that the Arg-Gly-Asp (RGD) in the penton base protein, the best known integrin binding motif, is only part of the binding interface with alpha3beta1, which involved multiple additional contact sites. (literal)

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