Different pattern of association of paraoxonase Gln192-Arg polymorphism with sporadic late-onset Alzheimer?s disease and coronary artery disease. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Different pattern of association of paraoxonase Gln192-Arg polymorphism with sporadic late-onset Alzheimer?s disease and coronary artery disease. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Scacchi R. , Gambina G., Martini M.C., Broggio E.,Vilardo T., and Corbo R.M. (2003)
  Different pattern of association of paraoxonase Gln192-Arg polymorphism with sporadic late-onset Alzheimer?s disease and coronary artery disease.
  in Neuroscience letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Scacchi R. , Gambina G., Martini M.C., Broggio E.,Vilardo T., and Corbo R.M. (literal)

Pagina inizio

• 17 (literal)

Pagina fine

• 20 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 339 (literal)

Rivista

• Neuroscience letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• R.M. Corbo è a disposizione dell'IBPM (literal)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Different pattern of association of paraoxonase Gln192-Arg polymorphism with sporadic late-onset Alzheimer?s disease and coronary artery disease. (literal)

Abstract

• The paraoxonase (PON1) Gln 192 - Arg polymorphism was examined in a group of sporadic late-onset Alzheimer's disease (AD) patients, in a group of coronary artery disease (CAD) patients, and in normal subjects. The AD sample showed a PON1*R allele frequency significantly lower than the control group (0.225 vs 0.281, p = 0.049). In the CAD patients the *R allele was more frequent than in the controls (0.230 vs. 0.213), though not significantly (p = 0.28). The odds ratios adjusted for age, gender, and APOE polymorphism by logistic regression analysis highlighted that in AD the PON1 RR genotype was significantly protective (OR = 0.41, 95% CI = 0.19 - 0.90; p = 0.025), whereas in CAD it appeared to be a significant risk factor (OR = 5.11, 95% CI = 1.09 - 23.9; p = 0.038) limited to younger patients. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• RENATO SCACCHI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR di

• RENATO SCACCHI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience letters (Rivista)