Synthesis and Degradation of Nucleic Acid Components by Formamide and Iron Sulphur Minerals. (Articolo in rivista)

Type
Label
  • Synthesis and Degradation of Nucleic Acid Components by Formamide and Iron Sulphur Minerals. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Saladino R., V. Neri, C. Crestini, G. Costanzo, M. Graciotti, E. Di Mauro (2008)
    Synthesis and Degradation of Nucleic Acid Components by Formamide and Iron Sulphur Minerals.
    in Journal of the American Chemical Society (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Saladino R., V. Neri, C. Crestini, G. Costanzo, M. Graciotti, E. Di Mauro (literal)
Pagina inizio
  • 15512 (literal)
Pagina fine
  • 15518 (literal)
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  • 130 (literal)
Rivista
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  • 7 (literal)
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  • 46 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • Dipartimento di Agrobiologia ed Agrochimica, UniVersita` della Tuscia, Viterbo, Italy, Dipartimento di Scienze e Tecnologie Chimiche, UniVersita` Tor Vergata, Roma 00100, Italy, Istituto di Biologia e Patologia Molecolari, CNR, Roma, Italy, and Dipartimento di Genetica e Biologia Molecolari, UniVersita` \"Sapienza\", Roma 00185, Italy (literal)
Titolo
  • Synthesis and Degradation of Nucleic Acid Components by Formamide and Iron Sulphur Minerals. (literal)
Abstract
  • We describe the one-pot synthesis of a large panel of nucleic bases and related compounds from formamide in the presence of iron sulfur and iron-copper sulfur minerals as catalysts. The major products observed are purine, 1H-pyrimidinone, isocytosine, adenine, 2-aminopurine, carbodiimide, urea, and oxalic acid. Isocytosine and 2-aminopurine may recognize natural nucleobases by Watson-Crick and reverse Watson-Crick interactions, thus suggesting novel scenarios for the origin of primordial nucleic acids. Since the major problem in the origin of informational polymers is the instability of their precursors, we also investigate the effects of iron sulfur and iron-copper sulfur minerals on the stability of ribooligonucleotides in formamide and in water. All of the iron sulfur and iron-copper sulfur minerals stimulated degradation of RNA. The relevance of these findings with respect to the origin of informational polymers is discussed. (literal)
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