http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11264
Assessment of the potential genotoxic risk of Phyllantus orbicularis HBK aqueous extract using in vitro and in vivo assays (Articolo in rivista)
- Type
- Label
- Assessment of the potential genotoxic risk of Phyllantus orbicularis HBK aqueous extract using in vitro and in vivo assays (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Sanchez Lamar A., Fuentes J.l., Fonseca G., Capiro N., Ferrer M., Alonzo A., Baluja L., Cozzi R., De Salvia R., Fiore M., Llagostera M. (2002)
Assessment of the potential genotoxic risk of Phyllantus orbicularis HBK aqueous extract using in vitro and in vivo assays
in Toxicology letters
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Sanchez Lamar A., Fuentes J.l., Fonseca G., Capiro N., Ferrer M., Alonzo A., Baluja L., Cozzi R., De Salvia R., Fiore M., Llagostera M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Assessment of the potential genotoxic risk of Phyllantus orbicularis HBK aqueous extract using in vitro and in vivo assays (literal)
- Abstract
- Phyllanthus orbicularis HBK is an endemic Cuban plant whose aqueous extract
has been proposed as an effective drug for the treatment of viral diseases.
In addition, antimutagenic properties of this extract have also been
reported. In the present study, the genotoxicity of this plant extract was
assessed using different in vitro and in vivo assays. Results from SOS gene
induction, gene reversion and conversion, and SMART assays clearly show
that P. orbicularis aqueous extract does not induce either primary DNA
damage or mutation. Additionally, no statistically significant difference
was found in the percentage of chromosomal aberrations in Chinese hamster
ovarian (CHO) cells treated with the plant extract. On the contrary,
micronuclei and abnormal anaphase were induced by this extract in CHO
cells. This genotoxic effect was related to a high cytotoxicity.Single
spots were detected in the SMART assay. These results point to a possible
aneugenic effect of the P. orbicularis aqueous extract at cytotoxic doses
which are much higher than those seen by their antiviral and antimutagenic
activities. (literal)
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