http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11246
Aminoglycosides as substrates and inhibitors of peroxidases (Articolo in rivista)
- Type
- Label
- Aminoglycosides as substrates and inhibitors of peroxidases (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Lorrai A., Padiglia A., Medda R., Bellelli A., Arcovito A., Floris G. (2002)
Aminoglycosides as substrates and inhibitors of peroxidases
in Journal of protein chemistry (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Lorrai A., Padiglia A., Medda R., Bellelli A., Arcovito A., Floris G. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- progetto di ricerca n. 23 - resp. L. Morpurgo (literal)
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Aminoglycosides as substrates and inhibitors of peroxidases (literal)
- Abstract
- The kinetics of the catalytic cycle of myeloperoxidase and of
horseradish peroxidase reacting with aminoglycosides have been
studied by conventional and stopped-flow spectrophotometry.
Aminoglycosides acted as one-electron reducing substrates converting
compound I, formed when stoichiometric amounts of hydrogen peroxide
were added to the enzyme, to compound II, and compound II to the
resting, ferric enzyme. The latter gradually decayed into a further
spectroscopic derivative (lambda(max) = 540 and 403 nm) tentatively
identified as a complex of ferric heme with the antibiotic oxidation
product(s), and the resulting enzyme was fully inactivated. Since
myeloperoxidase is the only human enzyme known to convert chloride
ions into the cytotoxic hypochlorous acid, the data presented in this
paper bear relevance to the pharmacological effects of aminoglycoside
antibiotics, which, while inhibiting bacterial growth, also prevent
oxidative cellular damage caused by hypochlorous acid aging as
substrates and inhibitors of myeloperoxidase.
(literal)
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