Pharmaceutical proteins in plants. A strategic genetic engineering approach for the production of tuberculosis antigens (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Pharmaceutical proteins in plants. A strategic genetic engineering approach for the production of tuberculosis antigens (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1196/annals.1428.089 (literal)

Alternative label

• Frutos R., Denise H., Vivares C., Neuhaus J.M., Vitale A., Pedrazzini E., Ma J., Dix P., Gray J., Pezzotti M., Conrad U., Robinson D. (2008) (2008)
  Pharmaceutical proteins in plants. A strategic genetic engineering approach for the production of tuberculosis antigens
  in Annals of the New York Academy of Sciences
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Frutos R., Denise H., Vivares C., Neuhaus J.M., Vitale A., Pedrazzini E., Ma J., Dix P., Gray J., Pezzotti M., Conrad U., Robinson D. (2008) (literal)

Pagina inizio

• 275 (literal)

Pagina fine

• 280 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://onlinelibrary.wiley.com/doi/10.1196/annals.1428.089/full (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 1149 (literal)

Rivista

• Annals of the New York Academy of Sciences (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• RF,French Agricultural Research Center for International Development, Montpellier, France HD, CV, Université Blaise Pascal Clermont-Ferrand II, Aubière, France J-MN,Université de Neuchatel, Neuchatel, Switzerland SV, EP, Istituto di Biologia e di Biotecnologia Agraria, Milano, Italy JM, St. George's Hospital, London, UK PD, National University of Ireland, Maynooth, Ireland JG, University of Cambridge, Cambridge, United Kingdom MP, Universita di Verona, Verona, Italy UC, Universitat Gatersleben, Gatersleben, Germany DR, Universitat Heidelberg, Heidelberg, Germany (literal)

Titolo

• Pharmaceutical proteins in plants. A strategic genetic engineering approach for the production of tuberculosis antigens (literal)

Abstract

• Tuberculosis (TB) is a re-emerging disease that is considered a major human health priority aswell as an important disease of livestock. TB is also a zoonosis, and Mycobacterium tuberculosis and M. bovis, the human and bovine causative agents, respectively, are very closely related. Protection against TB is essentially achieved through vaccination with the Bacille Calmetle-Guerin (BCG) strain of M. bovis. Protection is, however, incomplete, and novel improved vaccines are currently under investigation. Production of protective antigens in transgenic plants, or \"pharming,\" is a promising emerging approach, and a zoonosis-like TB is a good model for investigating the potential of this approach. Pharma-Planta, a European Commission-funded project and consortium, was set up to address this topic, within which a component is aimed at assessing the production efficacy and stability of the TB antigens in different compartments of the plant cell. This article ismeant to introduce this promising approach for veterinary medicine by describing the ongoing project and its specific genetic engineering strategy. (literal)

Prodotto di

• Institute of agricultural biology and biotechnology (IBBA) (Istituto)
• Basi molecolari, fisiologiche e cellulari delle produzioni vegetali. (AG.P01.001.001) (Modulo)
• Biotecnologie agro-industriali per il miglioramento genetico, il rispetto dell'ambiente e la tutela dei prodotti, la produzione di proteine e metaboliti di interesse alimentare, salutistico e farmacologico. (AG.P01.004.001) (Modulo)

Autore CNR

• ALESSANDRO VITALE (Unità di personale interno)
• EMANUELA PEDRAZZINI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Pharmaceutical proteins in plants. A strategic genetic engineering approach for the production of tuberculosis antigens" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of agricultural biology and biotechnology (IBBA) (Istituto)
• Biotecnologie agro-industriali per il miglioramento genetico, il rispetto dell'ambiente e la tutela dei prodotti, la produzione di proteine e metaboliti di interesse alimentare, salutistico e farmacologico. (AG.P01.004.001) (Modulo)
• Basi molecolari, fisiologiche e cellulari delle produzioni vegetali. (AG.P01.001.001) (Modulo)

Autore CNR di

• EMANUELA PEDRAZZINI (Unità di personale interno)
• ALESSANDRO VITALE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Annals of the New York Academy of Sciences (Rivista)

Insieme di parole chiave di

• Parole chiave di "Pharmaceutical proteins in plants. A strategic genetic engineering approach for the production of tuberculosis antigens" (Insieme di parole chiave)