Regional cardiac expression of biomarker of biomarkers involved in apoptotic process in an experimental model of left ventricular pacing-induced heart failure (Abstract/Comunicazione in atti di convegno)

Type

• Abstract/Comunicazione in atti di convegno (Classe)
• Prodotto della ricerca (Classe)

Label

• Regional cardiac expression of biomarker of biomarkers involved in apoptotic process in an experimental model of left ventricular pacing-induced heart failure (Abstract/Comunicazione in atti di convegno) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Prescimone T.; Colotti C.; Del Ry S.; Lionetti V.; Caselli C.; Cabiati M.; Emdin M.; Recchia F.; Giannessi D. (2010)
  Regional cardiac expression of biomarker of biomarkers involved in apoptotic process in an experimental model of left ventricular pacing-induced heart failure
  in Heart Failure Congress, Berlin
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Prescimone T.; Colotti C.; Del Ry S.; Lionetti V.; Caselli C.; Cabiati M.; Emdin M.; Recchia F.; Giannessi D. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: HF Congress - Heart Failure Congress (Berlin, 29 May-01June 2010). Abstract, vol. Supplements 9 article n. S154. European Journal of Heart Failure, 2010. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Purpose: Apoptosis plays a key role in the pathogenesis of heart failure (HF) contributing importantly to cell loss in the heart. Aim of this study was to assess the expression of apoptosis biochemical mediators in cardiac tissue of minipigs undergone pacing-induced HF, focusing attention on regional cardiac expression of apoptotic biomarkers, in order to better describe the apoptosis role in HF pathophysiology. Methods: Thirteen adult male minipigs (35--40 kg) were chronically instrumented with an unipolar pacemaker connected to the epicardial surface of the left ventricle (LV) anterior wall to induce HF by rapid LV pacing (180 beats/min). End-stage HF occurred at 21±2 days of pacing (LV end-diastolic pressure e20 mmHg). As control, 5 healthy adult male minipigs were also studied. mRNA expression of Caspase (Casp)-3, Casp-9 and their regulatory systems, Bcl-2 and Hsp72, respectively, were determined by semi-quantitative RT-PCR analysis in cardiac tissue from pacing site (PS) and opposite site (OS) wall of the LV. The apoptotic index was evaluated by TUNEL test. As inflammatory indices, Tumor Necrosis Factor (TNF)-a and Interleuchin (IL)-6 were also determined. Results: After 21 days of pacing, LVEF% was 24.0±3.7 (mean±sem) vs. 70.8±3.7 at baseline (p0.001). A significant decrease in LV end-systolic wall thickening was found in the PS (p (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-IFC, Pisa, Scuola Superiore Sant'Anna, Pisa (Italy), Sector of Medicine, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy (literal)

Titolo

• Regional cardiac expression of biomarker of biomarkers involved in apoptotic process in an experimental model of left ventricular pacing-induced heart failure (literal)

Prodotto di

• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• FABIO ANASTASIO RECCHIA (Persona)
• SILVIA DEL RY (Unità di personale interno)
• DANIELA GIANNESSI (Unità di personale interno)
• MICHELE EMDIN (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Regional cardiac expression of biomarker of biomarkers involved in apoptotic process in an experimental model of left ventricular pacing-induced heart failure" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DANIELA GIANNESSI (Unità di personale interno)
• SILVIA DEL RY (Unità di personale interno)
• MICHELE EMDIN (Unità di personale esterno)
• FABIO ANASTASIO RECCHIA (Persona)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)

Insieme di parole chiave di

• Keywords of "Regional cardiac expression of biomarker of biomarkers involved in apoptotic process in an experimental model of left ventricular pacing-induced heart failure" (Insieme di parole chiave)