http://www.cnr.it/ontology/cnr/individuo/prodotto/ID109318

Adenosine receptors mRNA expression in normal and failing minipig heart (Abstract/Comunicazione in atti di convegno)

Type

Label

Adenosine receptors mRNA expression in normal and failing minipig heart (Abstract/Comunicazione in atti di convegno) (literal)

Anno

Alternative label

Del Ry S.; Cabiati M.; Belcastro E.; Simioniuc A.; Caselli C.; Prescimone T.; Giannessi D. (2010)
Adenosine receptors mRNA expression in normal and failing minipig heart
in Heart Failure Congress, Berlin
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Del Ry S.; Cabiati M.; Belcastro E.; Simioniuc A.; Caselli C.; Prescimone T.; Giannessi D. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

In: HF Congress - Heart Failure Congress (Berlin, 29 May - 01 June 2010). Abstract, vol. Supplements 9 article n. S219. European Journal of Heart Failure,, 2010. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

Background: Chronic heart failure (HF) results in possibly beneficial endogenous adenosina accumulation. The final biological action of adenosine in a particular organ or cell population may depend on the relative expression level and signaling efficiency of the individual adenosine receptor (AR) subtypes. Aim: To determine myocardial expression of ARs, in the different chambers of failing compared to normal minipig hearts. Materials and Methods: Cardiac tissue (left and right atrium, left and right ventricle) was collected from male adult minipigs without (control, C, n=5) and with pacing-induced HF (n=5). ARs mRNA expression was evaluated by RT-PCR together with TNF--a mRNA expression. Results: A1R, A2AR, A2BR and A3R were expressed in all cardiac regions analyzed and, after 3 weeks of pacing, in left ventricle mRNA of each ARs resulted more expressed that in controls(A3R/gapdh: C=0.2±0.07 vs. HF: 1.4±0.5 p=0.03). TNF--a mRNA expression resulted significantly higher in left ventricle of HF pig (p=0.009). We also observed a significant correlation between TNF--a mRNA expression and A1R (r=0.6 p=0.0002), A2AR (r=0.8 p0.0001), A2BR (r (literal)

Note