Natriuretic peptide receptors A and C: sequencing and cardiac mRNA expression in normal and heart failure pigs (Abstract in rivista)

Type

• Abstract in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Natriuretic peptide receptors A and C: sequencing and cardiac mRNA expression in normal and heart failure pigs (Abstract in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Cabiati M.; Campan M.; Caselli C.; Prescimone T.; Giannessi D.; Del Ry S. (2010)
  Natriuretic peptide receptors A and C: sequencing and cardiac mRNA expression in normal and heart failure pigs
  
  (literal)

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• Cabiati M.; Campan M.; Caselli C.; Prescimone T.; Giannessi D.; Del Ry S. (literal)

Pagina inizio

• 125 (literal)

Pagina fine

• 126 (literal)

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• Conference: ESC Congress Location: Stockholm, SWEDEN Date: AUG 28-SEP 01, 2010 (literal)

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• 31 (literal)

Rivista

• European heart journal (Rivista)

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• In: ESC Congress - European Society of Cardiology Congress (Stockolm, 28 august - 01 september 2010). Abstract, article n. P802. ESC, 2010. (literal)

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• 1 (literal)

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• Pourpose: Natriuretic peptide receptors (NPRs) are capable to inhibit cardiac remodelling in heart failure (HF) targeted by novel pharmacological treatments, but their sequencing is still missing in minipig, the elective experimental model of HF. The pig constitutes an animal model largely used in experimental pathology owing of its similarity with human anatomo-physiology but Sus Scrofa genoma is not completely sequenced. Aim: to complete the characterization of NPR system in Sus Scrofa, sequencing NPR-A and NPR-C and to evaluate NPRs mRNA expression in experimental minipig HF models. Methods: to sequence NPR-A and NPR-C gene in Sus Scrofa we exploited the high homology between species, in particular between human and pig. For this reason, the optimal conditions were obtained using human cardiac tissue deriving from left ventricle (LV) of patients undergoing heart transplantation. ANP, BNP, NPR-A and NPR-C mRNA expressions were evaluated using cardiac tissue samples collected from adult male minipigs (weight 35-40 kg) without (control, n=4) and with pacing-induced HF (n=5). Results: Pig NPR-A and NPR-C mRNA were sequenced and resulted in 179 and 203 bp, respectively (GenBank accession n°: FJ518622, FJ518621 respectively). Compared to control, ANP and BNP gene expression resulted higher in all the cardiac chambers of HF heart. This increase is associated to a down-regulation of NPR-A and an up-regulation of NPR-C in HF. Conclusions: NPR-A and NPR-C gene in Sus Scrofa were sequenced and their mRNA expression were characterized simultaneously in all cardiac chambers of normal and HF minipigs. These sequences provide a new tool to investigate the role of NPs system under physiological and pathological conditions and their response to therapeutic interventions. (literal)

Note

• Abstract (literal)
• ISI Web of Science (WOS) (literal)

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• Scuola Superiore Sant'Anna, Pisa (Italy), Sector of Medicine, CNR-IFC, Pisa (literal)

Titolo

• Natriuretic peptide receptors A and C: sequencing and cardiac mRNA expression in normal and heart failure pigs (literal)

Prodotto di

• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• CHIARA CASELLI (Unità di personale interno)
• SILVIA DEL RY (Unità di personale interno)
• TOMMASO PRESCIMONE (Unità di personale esterno)
• Manuela Cabiati (Persona)
• DANIELA GIANNESSI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Natriuretic peptide receptors A and C: sequencing and cardiac mRNA expression in normal and heart failure pigs" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DANIELA GIANNESSI (Unità di personale interno)
• SILVIA DEL RY (Unità di personale interno)
• CHIARA CASELLI (Unità di personale interno)
• Manuela Cabiati (Persona)
• TOMMASO PRESCIMONE (Unità di personale esterno)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European heart journal (Rivista)

Insieme di parole chiave di

• Parole chiave di "Natriuretic peptide receptors A and C: sequencing and cardiac mRNA expression in normal and heart failure pigs" (Insieme di parole chiave)