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Measuring improvement of prenatal diagnosis efficiency in Tuscany. (Abstract/Poster in rivista)

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Measuring improvement of prenatal diagnosis efficiency in Tuscany. (Abstract/Poster in rivista) (literal)

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Pierini A.; Minichilli F.; Pieroni F.; Rial M.; Strigini F.; Bianchi F. (2010)
Measuring improvement of prenatal diagnosis efficiency in Tuscany.
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Pierini A.; Minichilli F.; Pieroni F.; Rial M.; Strigini F.; Bianchi F. (literal)

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In: Epedemiologia & Prevenzione. Abstract, vol. 34 (5-6) pp. 166 - 166. Supplemento 1. Inferenze e AIE Associazione Italiana di Epidemiologia, 2010. (literal)

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INTRODUCTION Congenital anomalies represent a major cause of infant mortality, childhood morbidity and long-term disability, with a prevalence at birth of 3-5%. The Tuscany Register of Congenital Defects (RTCD) was set up in 1992 to guarantee full registration of cases in the Region. OBJECTIVES To assess whether gestational age (GA) at diagnosis of selected congenital defects (CDs) has decreased over years in Tuscany. METHODS Data of RTCD on births and terminated pregnancies with prenatal diagnosis of isolated CDs among 458,278 total births surveilled over 1992-2008 was considered. Analysis was performed over three periods of time (1992-1996, 1997-2002, 2003-2008). Defects were selected among those more likely to be prenatally diagnosed: anencephaly, spina bifida, encephalocele, holoprosencephaly, omphalocele, gastroschisis, bilateral renal agenesis, transposition of great vessels (TGV), Fallot's tetralogy, hypoplastic left heart, common atrio-ventricular canal, single ventricle. Diagnostic efficiency was evaluated comparing mean gestational age differences (MGADs) at prenatal diagnosis among each period of time by univariate ANOVA, Bonferroni test and linear regression. RESULTS Earlier GA at diagnosis resulted for almost all CDs. Spina bifida and hypoplastic left heart showed statistically significant MGADs for GA at diagnosis between the third and the first period (respectively MGAD=-2.86p0.04; MGAD (literal)

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