Insulin secretion, ²-cell glucose sensitivity and insulin resistance in severe obesity: effect of massive weight loss after gastric bypass (Abstract/Poster in atti di convegno)

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  • Insulin secretion, ²-cell glucose sensitivity and insulin resistance in severe obesity: effect of massive weight loss after gastric bypass (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
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  • Marin D.; Monte Alegre S.; Ortiz J.; Pareja C.; Silva C.; Souza A.; Gastaldelli A.; Muscelli E. (2007)
    Insulin secretion, ²-cell glucose sensitivity and insulin resistance in severe obesity: effect of massive weight loss after gastric bypass
    in 43rd EASD Annual Meeting, Amsterdam
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Marin D.; Monte Alegre S.; Ortiz J.; Pareja C.; Silva C.; Souza A.; Gastaldelli A.; Muscelli E. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: 43rd EASD Annual Meeting (Amsterdam, 17-21 September 2007). Proceedings, pp. S262 - S262. EASD (ed.). EASD, 2007. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Background and Aims: The aims of this study were to evaluate the contribution of insulin resistance and impaired ²-cell function to glucose tolerance in severely obese subjects and to evaluate the effect of massive weight loss by Roux-en-Y Gastric bypass, RGB-Y, on the adaptation of insulin secretion to insulin resistance (IR). Materials and Methods: 34 obese (17 OB-NGT, 11 OB-IGT and 6 type 2 diabetic - OB-T2D; age 37.3±1.4y; BMI 50.0±1.5kg/m2) and 10 healthy lean CT (BMI 22.3±0.6kg/m2; 35±4y). Protocol: euglycemic hyperinsulinemic clamp (3h-insulin infusion at 240pmol/min.m-2) with indirect calorimetry, IVGTT and OGTT was used. 14 patients (11OB-NGT and 3OB-IGT) were re-evaluated post-surgery after weight stabilization ~18 months. Total (T-ISR) and fasting insulin secretion (f-ISR) were evaluated by C-peptide deconvolution and ²-cell glucose sensitivity (²-GS) as the slope of the insulin secretion/glucose concentration dose-response curve. The disposition index was calculated as ISRxMvalue of the clamp. Results: Obese subjects were insulin resistant for oxidative, nonoxidative and whole body glucose disposal (OB-T2D, OB-IGT and OB-NGT were ~30%, 60% and 43% of CT). During IVGTT the acute insulin response (AIR0-10min) was significantly higher in OB-NGT than in CT and in the other obese groups (CT 5378±590; OB-NGT 9363±895; OB-IGT 6544±558 and OB-T2D 3893±622 pmol.min-1.m-2), T-ISR was elevated in all obese groups (CT 20.2±1.9; OB-NGT 39.2±3.6; OB-IGT 39.2±2.5 and OB-T2D 37.1±4.5 nmol.min-1.m-2x60min) while ²-GS was decreased in OB-IGT and -T2D but not in -NGT as compared to CT (OB-T2D -4±3; OB-IGT 31±4; OB-NGT 56±6 and CT 43±6 pmol.min-1.m-2.mM-1). The disposition index was reduced in OB-IGT and -T2D but not in -NGT. After weight loss BMI was 30.2±1.2kg.m-2, f-ISR (from 148±12 to 83±12, p0.05 vs. pre; p (literal)
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  • Insulin secretion, ²-cell glucose sensitivity and insulin resistance in severe obesity: effect of massive weight loss after gastric bypass (literal)
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